Maternal protein intake is not associated with infant blood pressure

Susanna Y. Huh, Sheryl L. Rifas-Shiman, Ken P. Kleinman, Janet W. Rich-Edwards, Steven E Lipshultz, Matthew W. Gillman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Animal data show that low protein intake in pregnancy programs higher offspring blood pressure, but similar data in humans are limited. We examined the associations of first and second trimester maternal protein intake with offspring blood pressure (BP) at the age of six months. Methods: In a prospective US cohort study, called Project Viva, pregnant women completed validated semi-quantitative food-frequency questionnaires (FFQ) to measure gestational protein intake. Among 947 mother-offspring pairs with first trimester dietary data and 910 pairs with second trimester data, we measured systolic blood pressure (SBP) up to five times with an automated device in the offspring at the age of six months. Controlling for blood pressure measurement conditions, maternal and infant characteristics, we examined the effect of energy-adjusted maternal protein intake on infant SBP using multivariable mixed effects models. Results: Mean daily second trimester maternal protein intake was 17.6% of energy (mean 2111 kcal/day). First trimester nutrient intakes were similar. Mean SBP at age 6 months was 90.0 mm Hg (SD 12.9). Consistent with prior reports, adjusted SBP was 1.94 mm Hg lower [95% confidence interval (CI) -3.45 to -0.42] for each kg increase in birth weight. However, we did not find an association between maternal protein intake and infant SBP. After adjusting for covariates, the effect estimates were 0.14 mm Hg (95% CI -0.12 to -0.40) for a 1% increase in energy from protein during the second trimester, and -0.01 mm Hg (95% CI -0.24 to -0.23) for a 1% increase in energy from protein in the first trimester. Conclusions: Variation in maternal total protein intake during pregnancy does not appear to program offspring blood pressure.

Original languageEnglish
Pages (from-to)378-384
Number of pages7
JournalInternational Journal of Epidemiology
Volume34
Issue number2
DOIs
StatePublished - Apr 1 2005

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Mothers
Blood Pressure
Proteins
Second Pregnancy Trimester
First Pregnancy Trimester
Confidence Intervals
Food
Pregnancy
Birth Weight
Pregnant Women
Cohort Studies
Hypertension
Equipment and Supplies

Keywords

  • Blood pressure
  • Diet surveys
  • Fetal programming
  • Infant
  • Pregnancy
  • Protein
  • Systolic

ASJC Scopus subject areas

  • Epidemiology

Cite this

Huh, S. Y., Rifas-Shiman, S. L., Kleinman, K. P., Rich-Edwards, J. W., Lipshultz, S. E., & Gillman, M. W. (2005). Maternal protein intake is not associated with infant blood pressure. International Journal of Epidemiology, 34(2), 378-384. https://doi.org/10.1093/ije/dyh373

Maternal protein intake is not associated with infant blood pressure. / Huh, Susanna Y.; Rifas-Shiman, Sheryl L.; Kleinman, Ken P.; Rich-Edwards, Janet W.; Lipshultz, Steven E; Gillman, Matthew W.

In: International Journal of Epidemiology, Vol. 34, No. 2, 01.04.2005, p. 378-384.

Research output: Contribution to journalArticle

Huh, SY, Rifas-Shiman, SL, Kleinman, KP, Rich-Edwards, JW, Lipshultz, SE & Gillman, MW 2005, 'Maternal protein intake is not associated with infant blood pressure', International Journal of Epidemiology, vol. 34, no. 2, pp. 378-384. https://doi.org/10.1093/ije/dyh373
Huh SY, Rifas-Shiman SL, Kleinman KP, Rich-Edwards JW, Lipshultz SE, Gillman MW. Maternal protein intake is not associated with infant blood pressure. International Journal of Epidemiology. 2005 Apr 1;34(2):378-384. https://doi.org/10.1093/ije/dyh373
Huh, Susanna Y. ; Rifas-Shiman, Sheryl L. ; Kleinman, Ken P. ; Rich-Edwards, Janet W. ; Lipshultz, Steven E ; Gillman, Matthew W. / Maternal protein intake is not associated with infant blood pressure. In: International Journal of Epidemiology. 2005 ; Vol. 34, No. 2. pp. 378-384.
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abstract = "Background: Animal data show that low protein intake in pregnancy programs higher offspring blood pressure, but similar data in humans are limited. We examined the associations of first and second trimester maternal protein intake with offspring blood pressure (BP) at the age of six months. Methods: In a prospective US cohort study, called Project Viva, pregnant women completed validated semi-quantitative food-frequency questionnaires (FFQ) to measure gestational protein intake. Among 947 mother-offspring pairs with first trimester dietary data and 910 pairs with second trimester data, we measured systolic blood pressure (SBP) up to five times with an automated device in the offspring at the age of six months. Controlling for blood pressure measurement conditions, maternal and infant characteristics, we examined the effect of energy-adjusted maternal protein intake on infant SBP using multivariable mixed effects models. Results: Mean daily second trimester maternal protein intake was 17.6{\%} of energy (mean 2111 kcal/day). First trimester nutrient intakes were similar. Mean SBP at age 6 months was 90.0 mm Hg (SD 12.9). Consistent with prior reports, adjusted SBP was 1.94 mm Hg lower [95{\%} confidence interval (CI) -3.45 to -0.42] for each kg increase in birth weight. However, we did not find an association between maternal protein intake and infant SBP. After adjusting for covariates, the effect estimates were 0.14 mm Hg (95{\%} CI -0.12 to -0.40) for a 1{\%} increase in energy from protein during the second trimester, and -0.01 mm Hg (95{\%} CI -0.24 to -0.23) for a 1{\%} increase in energy from protein in the first trimester. Conclusions: Variation in maternal total protein intake during pregnancy does not appear to program offspring blood pressure.",
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AB - Background: Animal data show that low protein intake in pregnancy programs higher offspring blood pressure, but similar data in humans are limited. We examined the associations of first and second trimester maternal protein intake with offspring blood pressure (BP) at the age of six months. Methods: In a prospective US cohort study, called Project Viva, pregnant women completed validated semi-quantitative food-frequency questionnaires (FFQ) to measure gestational protein intake. Among 947 mother-offspring pairs with first trimester dietary data and 910 pairs with second trimester data, we measured systolic blood pressure (SBP) up to five times with an automated device in the offspring at the age of six months. Controlling for blood pressure measurement conditions, maternal and infant characteristics, we examined the effect of energy-adjusted maternal protein intake on infant SBP using multivariable mixed effects models. Results: Mean daily second trimester maternal protein intake was 17.6% of energy (mean 2111 kcal/day). First trimester nutrient intakes were similar. Mean SBP at age 6 months was 90.0 mm Hg (SD 12.9). Consistent with prior reports, adjusted SBP was 1.94 mm Hg lower [95% confidence interval (CI) -3.45 to -0.42] for each kg increase in birth weight. However, we did not find an association between maternal protein intake and infant SBP. After adjusting for covariates, the effect estimates were 0.14 mm Hg (95% CI -0.12 to -0.40) for a 1% increase in energy from protein during the second trimester, and -0.01 mm Hg (95% CI -0.24 to -0.23) for a 1% increase in energy from protein in the first trimester. Conclusions: Variation in maternal total protein intake during pregnancy does not appear to program offspring blood pressure.

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