Maternal depression and medication exposure during pregnancy: Comparison of maternal retrospective recall to prospective documentation

Donald J Newport, P. A. Brennan, P. Green, D. Ilardi, T. H. Whitfield, N. Morris, B. T. Knight, Z. N. Stowe

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective: Outcome investigations of prenatal maternal depression and psychotropic exposure rely extensively on maternal retrospective recall. This study compared postnatal recall to prospective documentation of illness and medication exposures. Design: Prospective cohort and retrospective case-control studies. Setting: Emory Women's Mental Health Program (prospective study) and Emory University Department of Psychology (retrospective study). Sample: A total of 164 women who participated in both the prospective and retrospective studies. Methods: Women with a history of mental illness were followed during pregnancy for prospective prenatal assessments of depression and medication exposures. At 6 months postpartum, some of these women also participated in a retrospective study during which they were asked to recall prenatal depression and medication use. Agreement between prospective and retrospective documentation of exposures was analysed. Main outcome measures: Occurrence of maternal depression during pregnancy and maternal use of pharmacological agents during pregnancy. Results: There was only moderate agreement (k = 0.42) in prospective versus retrospective reporting of prenatal depression. Positive predictive value for recalling depression was 90.4%; however, negative predictive value for denying depression was only 53.8%. Participants accurately recalled psychotropic use but significantly underreported use of nonpsychotropic medications. Conclusions: Studies using retrospective data collection may be susceptible to systematic recall bias with underreporting of maternal depression and use of nonpsychotropic agents during pregnancy.

Original languageEnglish (US)
Pages (from-to)681-688
Number of pages8
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume115
Issue number6
DOIs
StatePublished - May 2008
Externally publishedYes

Fingerprint

Documentation
Mothers
Depression
Pregnancy
Retrospective Studies
Prospective Studies
Women's Health
Postpartum Period
Case-Control Studies
Mental Health
Outcome Assessment (Health Care)
Pharmacology
Psychology

Keywords

  • Depression
  • Postpartum
  • Pregnancy
  • Recall bias
  • Retrospective recall

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Maternal depression and medication exposure during pregnancy : Comparison of maternal retrospective recall to prospective documentation. / Newport, Donald J; Brennan, P. A.; Green, P.; Ilardi, D.; Whitfield, T. H.; Morris, N.; Knight, B. T.; Stowe, Z. N.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 115, No. 6, 05.2008, p. 681-688.

Research output: Contribution to journalArticle

Newport, Donald J ; Brennan, P. A. ; Green, P. ; Ilardi, D. ; Whitfield, T. H. ; Morris, N. ; Knight, B. T. ; Stowe, Z. N. / Maternal depression and medication exposure during pregnancy : Comparison of maternal retrospective recall to prospective documentation. In: BJOG: An International Journal of Obstetrics and Gynaecology. 2008 ; Vol. 115, No. 6. pp. 681-688.
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