Maternal depression: a child's first adverse life event.

D. Jeffrey Newport, Molly M. Wilcox, Zachary N. Stowe

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Can the effects of maternal depression upon offspring development be extrapolated to the prebirth environment, making it the earliest of adverse life events? Increasing clinical and laboratory data indicate that maternal stress and depression during critical developmental windows carry a diverse array of harmful sequelae for the offspring. The effects witnessed in animal research include neurobiological and behavioral alterations that persist into adulthood. Paralleling the preclinical literature are human studies indicating similar acute effects. The clinical implications for the psychiatric treatment of depressed women who have children will be discussed.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
JournalSeminars in clinical neuropsychiatry
Issue number2
StatePublished - Apr 2002
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology


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