Maternal calcium intake during pregnancy and blood pressure in the offspring at age 3 years: A follow-up analysis of the project viva cohort

Rachel Bakker, Sheryl L. Rifas-Shiman, Ken P. Kleinman, Steven E Lipshultz, Matthew W. Gillman

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A previous analysis of the Project Viva cohort (eastern Massachusetts, 1999-2002 recruitment) found an association between higher second-trimester supplemental maternal calcium intake and lower systolic blood pressure in offspring at 6 months. The authors analyzed 5,527 systolic blood pressure measurements from 1,173 mother-child pairs from this same cohort when the children were aged 3 years. They estimated the change in offspring blood pressure for a 500-mg difference in maternal total, dietary-only, and supplemental-only calcium intake during the first 2 trimesters of pregnancy. Mean daily total calcium intake was 1,311 mg (standard deviation, 421) in the first trimester and 1,440 mg (standard deviation, 386) in the second trimester. Mean systolic blood pressure of the offspring at age 3 years was 92.1 mm Hg (standard deviation, 10.3). None of the maternal calcium intake measures during the first and second trimesters was associated with systolic blood pressure in the offspring. For example, for each 500-mg increment in maternal total elemental calcium intake in the second trimester, child's 3-year systolic blood pressure was 0.1 mm Hg lower (95% confidence interval: -0.9, 0.6). Maternal calcium intake during pregnancy was not associated with offspring blood pressure at the age of 3 years.

Original languageEnglish
Pages (from-to)1374-1380
Number of pages7
JournalAmerican Journal of Epidemiology
Volume168
Issue number12
DOIs
StatePublished - Dec 1 2008

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Mothers
Blood Pressure
Calcium
Pregnancy
Second Pregnancy Trimester
First Pregnancy Trimester
Confidence Intervals

Keywords

  • Blood pressure
  • Calcium
  • Cardiovascular diseases
  • Child
  • Pregnancy

ASJC Scopus subject areas

  • Epidemiology

Cite this

Maternal calcium intake during pregnancy and blood pressure in the offspring at age 3 years : A follow-up analysis of the project viva cohort. / Bakker, Rachel; Rifas-Shiman, Sheryl L.; Kleinman, Ken P.; Lipshultz, Steven E; Gillman, Matthew W.

In: American Journal of Epidemiology, Vol. 168, No. 12, 01.12.2008, p. 1374-1380.

Research output: Contribution to journalArticle

Bakker, Rachel ; Rifas-Shiman, Sheryl L. ; Kleinman, Ken P. ; Lipshultz, Steven E ; Gillman, Matthew W. / Maternal calcium intake during pregnancy and blood pressure in the offspring at age 3 years : A follow-up analysis of the project viva cohort. In: American Journal of Epidemiology. 2008 ; Vol. 168, No. 12. pp. 1374-1380.
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