Materials for cell encapsulation via a new tandem approach combining reverse thermal gelation and covalent crosslinking

Francesco Cellesi, Nicola Tirelli, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The contemporary occurrence of a thermal gelation (by the occurrence of a lower critical solubility temperature, LCST) and of a chemical curing has allowed to use biocompatible polyethers (PEG, Pluronic) for mimicking sodium alginate gelation and perspectively substituting it for encapsulation purposes. The final materials were easily formed in cell culture media and perfectly passed a preliminary biocompatibility assessment. Additionally, they showed a stimuli responsive behavior, e.g. in the modulation of their swelling degree with temperature (preserving the LCST character of the precursors) and solvent composition.

Original languageEnglish
Pages (from-to)1466-1472
Number of pages7
JournalMacromolecular Chemistry and Physics
Volume203
Issue number10-11
DOIs
StatePublished - Jul 29 2002
Externally publishedYes

Fingerprint

gelation
Gelation
crosslinking
Encapsulation
Crosslinking
solubility
Solubility
cells
occurrences
Poloxamer
Sodium alginate
culture media
Polyethers
biocompatibility
curing
Biocompatibility
Cell culture
swelling
stimuli
Temperature

Keywords

  • Biomaterials
  • Cell encapsulation
  • LCST
  • Michael-type addition
  • Pluronic

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Materials for cell encapsulation via a new tandem approach combining reverse thermal gelation and covalent crosslinking. / Cellesi, Francesco; Tirelli, Nicola; Hubbell, Jeffrey A.

In: Macromolecular Chemistry and Physics, Vol. 203, No. 10-11, 29.07.2002, p. 1466-1472.

Research output: Contribution to journalArticle

Cellesi, Francesco ; Tirelli, Nicola ; Hubbell, Jeffrey A. / Materials for cell encapsulation via a new tandem approach combining reverse thermal gelation and covalent crosslinking. In: Macromolecular Chemistry and Physics. 2002 ; Vol. 203, No. 10-11. pp. 1466-1472.
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