Materials for cell encapsulation via a new tandem approach combining reverse thermal gelation and covalent crosslinking

Francesco Cellesi, Nicola Tirelli, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

The contemporary occurrence of a thermal gelation (by the occurrence of a lower critical solubility temperature, LCST) and of a chemical curing has allowed to use biocompatible polyethers (PEG, Pluronic) for mimicking sodium alginate gelation and perspectively substituting it for encapsulation purposes. The final materials were easily formed in cell culture media and perfectly passed a preliminary biocompatibility assessment. Additionally, they showed a stimuli responsive behavior, e.g. in the modulation of their swelling degree with temperature (preserving the LCST character of the precursors) and solvent composition.

Original languageEnglish (US)
Pages (from-to)1466-1472
Number of pages7
JournalMacromolecular Chemistry and Physics
Volume203
Issue number10-11
DOIs
StatePublished - Jul 29 2002

Keywords

  • Biomaterials
  • Cell encapsulation
  • LCST
  • Michael-type addition
  • Pluronic

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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