Materials engineering for immunomodulation

Jeffrey A. Hubbell, Susan N. Thomas, Melody A. Swartz

Research output: Contribution to journalReview article

392 Scopus citations

Abstract

The engineering of materials that can modulate the immune system is an emerging field that is developing alongside immunology. For therapeutic ends such as vaccine development, materials are now being engineered to deliver antigens through specific intracellular pathways, allowing better control of the way in which antigens are presented to one of the key types of immune cell, T cells. Materials are also being designed as adjuvants, to mimic specific 'danger' signals in order to manipulate the resultant cytokine environment, which influences how antigens are interpreted by T cells. In addition to offering the potential for medical advances, immunomodulatory materials can form well-defined model systems, helping to provide new insight into basic immunobiology.

Original languageEnglish (US)
Pages (from-to)449-460
Number of pages12
JournalNature
Volume462
Issue number7272
DOIs
StatePublished - Nov 26 2009

ASJC Scopus subject areas

  • General

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    Hubbell, J. A., Thomas, S. N., & Swartz, M. A. (2009). Materials engineering for immunomodulation. Nature, 462(7272), 449-460. https://doi.org/10.1038/nature08604