Materials engineering for immunomodulation

Jeffrey A. Hubbell, Susan N. Thomas, Melody A. Swartz

Research output: Contribution to journalArticle

376 Citations (Scopus)

Abstract

The engineering of materials that can modulate the immune system is an emerging field that is developing alongside immunology. For therapeutic ends such as vaccine development, materials are now being engineered to deliver antigens through specific intracellular pathways, allowing better control of the way in which antigens are presented to one of the key types of immune cell, T cells. Materials are also being designed as adjuvants, to mimic specific 'danger' signals in order to manipulate the resultant cytokine environment, which influences how antigens are interpreted by T cells. In addition to offering the potential for medical advances, immunomodulatory materials can form well-defined model systems, helping to provide new insight into basic immunobiology.

Original languageEnglish
Pages (from-to)449-460
Number of pages12
JournalNature
Volume462
Issue number7272
DOIs
StatePublished - Nov 26 2009
Externally publishedYes

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Immunomodulation
Antigens
T-Lymphocytes
Allergy and Immunology
Immune System
Vaccines
Cytokines
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Hubbell, J. A., Thomas, S. N., & Swartz, M. A. (2009). Materials engineering for immunomodulation. Nature, 462(7272), 449-460. https://doi.org/10.1038/nature08604

Materials engineering for immunomodulation. / Hubbell, Jeffrey A.; Thomas, Susan N.; Swartz, Melody A.

In: Nature, Vol. 462, No. 7272, 26.11.2009, p. 449-460.

Research output: Contribution to journalArticle

Hubbell, JA, Thomas, SN & Swartz, MA 2009, 'Materials engineering for immunomodulation', Nature, vol. 462, no. 7272, pp. 449-460. https://doi.org/10.1038/nature08604
Hubbell JA, Thomas SN, Swartz MA. Materials engineering for immunomodulation. Nature. 2009 Nov 26;462(7272):449-460. https://doi.org/10.1038/nature08604
Hubbell, Jeffrey A. ; Thomas, Susan N. ; Swartz, Melody A. / Materials engineering for immunomodulation. In: Nature. 2009 ; Vol. 462, No. 7272. pp. 449-460.
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