Materials as solid-phase therapeutics for in situ engineering of tissue regeneration

Jeffrey A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The two approaches used to develop biomaterials for in situ engineering of tissue regeneration are discussed. One of the approach is based on the customization of a natural cell invasion matrix, fibrin, and the other is based on synthetic mimetics of fibrin and collagen. The developed biomaterials present adhesion signals, possess protease-sensitive sites for materials degradation, and also present bound growth factors. The development of approaches by which to incorporate exogenous adhesion peptides, adhesion proteins, growth factor binding sites, and growth factors into fibrin during coagulation, exploiting the transglutaminase activity of the coagulation enzyme factor XIIIa are also discussed.

Original languageEnglish
Title of host publicationThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
StatePublished - Dec 1 2002
Externally publishedYes
EventThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States
Duration: Oct 13 2002Oct 16 2002

Other

OtherThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
CountryUnited States
CityAtlanta, GA
Period10/13/0210/16/02

Fingerprint

Tissue regeneration
Adhesion
Coagulation
Biomaterials
Binding sites
Collagen
Peptides
Enzymes
Proteins
Degradation
Intercellular Signaling Peptides and Proteins

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hubbell, J. A. (2002). Materials as solid-phase therapeutics for in situ engineering of tissue regeneration. In Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

Materials as solid-phase therapeutics for in situ engineering of tissue regeneration. / Hubbell, Jeffrey A.

Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products. 2002.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hubbell, JA 2002, Materials as solid-phase therapeutics for in situ engineering of tissue regeneration. in Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products, Atlanta, GA, United States, 10/13/02.
Hubbell JA. Materials as solid-phase therapeutics for in situ engineering of tissue regeneration. In Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products. 2002
Hubbell, Jeffrey A. / Materials as solid-phase therapeutics for in situ engineering of tissue regeneration. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products. 2002.
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