Materials as morphogenetic guides in tissue engineering

Jeffrey A. Hubbell

Research output: Contribution to journalArticle

290 Citations (Scopus)

Abstract

Within native tissues cells are held within the extracellular matrix (ECM), which has a role in maintaining homeostasis, guiding development and directing regeneration. Efforts in tissue engineering have aimed to mimick the ECM to help guide morphogenesis and tissue repair. Studies have not only looked at ways to mimick the structure and characteristics of the ECM, but have also considered ways to reproduce its molecular properties including its bioadhesive character, proteolytic susceptibility and ability to bind growth factors.

Original languageEnglish
Pages (from-to)551-558
Number of pages8
JournalCurrent Opinion in Biotechnology
Volume14
Issue number5
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

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Tissue Engineering
Tissue engineering
Extracellular Matrix
Tissue
Intercellular Signaling Peptides and Proteins
Repair
Morphogenesis
Regeneration
Homeostasis

ASJC Scopus subject areas

  • Biotechnology

Cite this

Materials as morphogenetic guides in tissue engineering. / Hubbell, Jeffrey A.

In: Current Opinion in Biotechnology, Vol. 14, No. 5, 01.10.2003, p. 551-558.

Research output: Contribution to journalArticle

Hubbell, Jeffrey A. / Materials as morphogenetic guides in tissue engineering. In: Current Opinion in Biotechnology. 2003 ; Vol. 14, No. 5. pp. 551-558.
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