Mast cells as modulators of hair follicle cycling

Marcus Maurer, Ralf Paus, Beate M. Czarnetzki

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Abstract While the central rôle of mast cells (MC) in allergy and inflammation is well‐appreciated, much less is known about their physiological functions. The impressive battery of potent growth modulatory MC products, and increasing evidence of MC involvement in hyperproliferalive and librotic disorders suggest that tissue remodelling may be one of those, namely in the skin. Here, we delineate why this may best be studied by analysing the potential role of MC in hair growth regulation. On the background of numerous, yet widely under‐appreciated hints from the older literature, we summarize and discuss our recent observations from the C57BL/6 mouse model for hair research which support the concept that MC are functionally important modulators of hair follicle cycling, specifically during anagen development. This invites to exploit the murinc hair cycle as a model for dissecting the physiological growth modulatory functions of MC and encourages the exploration of MC‐targeting pharmaceutical strategies for the treatment of hair growth disorders.

Original languageEnglish (US)
Pages (from-to)266-271
Number of pages6
JournalExperimental dermatology
Volume4
Issue number4
DOIs
StatePublished - Aug 1995
Externally publishedYes

Keywords

  • C57BU6 mouse
  • growth factors
  • hair follicle
  • hair growth
  • mast cells
  • tissue remodelling anagen

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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