Massive astrocytic swelling in response to extracellular glutamate--a possible mechanism for post-traumatic brain swelling?

W. L. Maxwell, Ross Bullock, H. Landholt, H. Fujisawa

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Little attention has been paid to the responses of astrocytes in the brain to the application of neurotoxic excitatory transmitters such as glutamate. We have developed a simple model to study the responses of cells within the cerebral cortex to neurotoxic levels of glutamate. After short periods of perfusion with glutamate, perivascular and interstitial astrocytes swell and become electron lucent. The astrocyte swelling extends, with increasing periods of perfusion, up to 400 um into the adjacent, intact neuropil. After 90 minutes of glutamate perfusion, intermediate filament bundles and glycogen granules occur within the astrocyte cytoplasm. We obtained no evidence for compromised blood flow. We suggest that astrocyte swelling serves to limit the diffusion of glutamate from the site of the lesion.

Original languageEnglish
Pages (from-to)465-467
Number of pages3
JournalActa Neurochirurgica, Supplement
Volume60
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

glutamates
Brain Edema
Astrocytes
swelling
brain
Swelling
Glutamic Acid
Brain
Perfusion
cerebral cortex
glycogens
Neuropil
Intermediate Filaments
cytoplasm
blood flow
Glycogen
Cerebral Cortex
lesions
transmitters
bundles

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Massive astrocytic swelling in response to extracellular glutamate--a possible mechanism for post-traumatic brain swelling? / Maxwell, W. L.; Bullock, Ross; Landholt, H.; Fujisawa, H.

In: Acta Neurochirurgica, Supplement, Vol. 60, 01.01.1994, p. 465-467.

Research output: Contribution to journalArticle

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