Marker rhythmometry with macrophage-colony stimulating factor (M-CSF).

S. Elg, E. Halberg, S. Ramakrishnan, G. Cornélissen, E. Haus, G. Nicolau, L. Carson, L. Twiggs, H. J. Long, F. Halberg

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In a patient with a debulked müllerian adenocarcinoma involving the ovary, an elevated serum concentration of macrophage-colony stimulating factor (M-CSF) (5.3 ng/ml) was lowered into the range of the age- and gender-matched controls by a 24-hour infusion of 135 mg/m2 of taxol, as was a Ca125 of 1480 U/ml by three such taxol courses given at 3-week intervals (to 14 U/ml). A downward trend of M-CSF in serum with an about-14-hour ultradian modulation during the first chemotherapy course resembles that of the concomitantly assessed Ca125. A decreasing trend modulated by an about-half-weekly component is found in M-CSF of fractionated urines collected at spontaneous voidings around the clock for 5 days. M-CSF may serve as a chronobiologic marker for optimizing, on an individualized basis, 1) the infradian scheduling of chemotherapy courses and 2) the ultradian-circadian within-course time patterns. Timing based on markers of the anticancer effect aims at teh as-yet unattained transfer from rodent to human of cancer cures that were not previously feasible without chronobiologic considerations. This goal can be pursued with M-CSF as well as Ca125 and UGP as possibly complementary chronobiologic markers in a chronotherapy trial with taxol in humans.

Original languageEnglish (US)
Pages (from-to)141-152
Number of pages12
JournalChronobiologia
Volume18
Issue number4
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

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    Elg, S., Halberg, E., Ramakrishnan, S., Cornélissen, G., Haus, E., Nicolau, G., Carson, L., Twiggs, L., Long, H. J., & Halberg, F. (1991). Marker rhythmometry with macrophage-colony stimulating factor (M-CSF). Chronobiologia, 18(4), 141-152.