Marker rhythmometry with macrophage-colony stimulating factor (M-CSF).

S. Elg, E. Halberg, Sundaram Ramakrishnan, G. Cornélissen, E. Haus, G. Nicolau, L. Carson, L. Twiggs, H. J. Long, F. Halberg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In a patient with a debulked müllerian adenocarcinoma involving the ovary, an elevated serum concentration of macrophage-colony stimulating factor (M-CSF) (5.3 ng/ml) was lowered into the range of the age- and gender-matched controls by a 24-hour infusion of 135 mg/m2 of taxol, as was a Ca125 of 1480 U/ml by three such taxol courses given at 3-week intervals (to 14 U/ml). A downward trend of M-CSF in serum with an about-14-hour ultradian modulation during the first chemotherapy course resembles that of the concomitantly assessed Ca125. A decreasing trend modulated by an about-half-weekly component is found in M-CSF of fractionated urines collected at spontaneous voidings around the clock for 5 days. M-CSF may serve as a chronobiologic marker for optimizing, on an individualized basis, 1) the infradian scheduling of chemotherapy courses and 2) the ultradian-circadian within-course time patterns. Timing based on markers of the anticancer effect aims at teh as-yet unattained transfer from rodent to human of cancer cures that were not previously feasible without chronobiologic considerations. This goal can be pursued with M-CSF as well as Ca125 and UGP as possibly complementary chronobiologic markers in a chronotherapy trial with taxol in humans.

Original languageEnglish
Pages (from-to)141-152
Number of pages12
JournalChronobiologia
Volume18
Issue number4
StatePublished - Oct 1 1991
Externally publishedYes

Fingerprint

Macrophage Colony-Stimulating Factor
Paclitaxel
Chronotherapy
Drug Therapy
Serum
Ovary
Rodentia
Adenocarcinoma
Urine
Neoplasms

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

Cite this

Elg, S., Halberg, E., Ramakrishnan, S., Cornélissen, G., Haus, E., Nicolau, G., ... Halberg, F. (1991). Marker rhythmometry with macrophage-colony stimulating factor (M-CSF). Chronobiologia, 18(4), 141-152.

Marker rhythmometry with macrophage-colony stimulating factor (M-CSF). / Elg, S.; Halberg, E.; Ramakrishnan, Sundaram; Cornélissen, G.; Haus, E.; Nicolau, G.; Carson, L.; Twiggs, L.; Long, H. J.; Halberg, F.

In: Chronobiologia, Vol. 18, No. 4, 01.10.1991, p. 141-152.

Research output: Contribution to journalArticle

Elg, S, Halberg, E, Ramakrishnan, S, Cornélissen, G, Haus, E, Nicolau, G, Carson, L, Twiggs, L, Long, HJ & Halberg, F 1991, 'Marker rhythmometry with macrophage-colony stimulating factor (M-CSF).', Chronobiologia, vol. 18, no. 4, pp. 141-152.
Elg S, Halberg E, Ramakrishnan S, Cornélissen G, Haus E, Nicolau G et al. Marker rhythmometry with macrophage-colony stimulating factor (M-CSF). Chronobiologia. 1991 Oct 1;18(4):141-152.
Elg, S. ; Halberg, E. ; Ramakrishnan, Sundaram ; Cornélissen, G. ; Haus, E. ; Nicolau, G. ; Carson, L. ; Twiggs, L. ; Long, H. J. ; Halberg, F. / Marker rhythmometry with macrophage-colony stimulating factor (M-CSF). In: Chronobiologia. 1991 ; Vol. 18, No. 4. pp. 141-152.
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