Background Metastatic basal cell carcinoma (BCC) is a rare but life-threatening condition. Prior estimates of overall survival (OS) from time of diagnosis of distant metastasis to death are approximately 8-14 months. However, these estimates are based on analyses of case reports published prior to 1984. Objectives To assess an updated OS in patients with metastatic BCC at a single academic institution. Methods Using patients seen from 1997 to 2011, a retrospective chart review was performed on biopsy-confirmed cases of distant metastatic BCC at Stanford University School of Medicine. Kaplan-Meier analysis was used to determine OS and progression-free survival (PFS). Results Ten consecutive cases of distant metastatic BCC were identified. Median OS was 7·3 years [95% confidence interval (CI) 1·6-∞]; median PFS was 3·4 years (95% CI 1·1-5·2). Conclusions Our findings suggest that OS in patients with distant metastatic BCC may be more favourable than previously reported. What's already known about this topic? The estimate of overall survival (OS) from date of diagnosis of distant metastatic basal cell carcinoma (BCC) to death is 8-14 months. This estimate was published in 1984 and needs to be updated. What does this study add? We explored OS in a series of patients from 1997 to 2011 at Stanford Hospital and Clinics. Our findings suggest that OS in patients with metastatic BCC may be more favourable than previously reported.
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