Marked reduction in serotonergic activity in a sexually aggressive adolescent male

Adarsh Kumar, Mahendra Kumar, Benjamin B. Lahey, Debra A. Katz, Benny Fernandez, Jon Shaw, Ana Campo, Charles Nemeroff

Research output: Contribution to journalArticle

Abstract

Serotonergic dysfunctions are implicated in conduct disorder, impulsivity, and aggression. Early adverse experiences increase the risk for these behaviors in adolescents. The authors investigated serotonergic activity in one adolescent male who experienced maternal abandonment and childhood abuse and exhibited severely aggressive sexual offenses. Platelet serotonin (5-HT) concentration, [14C]-5HT uptake kinetics, and plasma prolactin, cortisol response to D,L-fenfluramine (D,L-FEN) were measured. Results showed extremely low 5-HT concentration (2.960.7 ng/108 platelets), [14C]-5HT uptake rate (0.560.04 mM/min/ 107 platelets), undetectable Km and Vmax, and abnormally blunted prolactin, cortisol response to D,L-FEN. These abnormalities in this sexually aggressive adolescent may be a consequence of childhood abuse.

Original languageEnglish
Pages (from-to)262-270
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume26
Issue number3
DOIs
StatePublished - Jan 1 2014

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Fenfluramine
Serotonin
Blood Platelets
Prolactin
Hydrocortisone
Conduct Disorder
Impulsive Behavior
Risk-Taking
Aggression
Mothers

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Marked reduction in serotonergic activity in a sexually aggressive adolescent male. / Kumar, Adarsh; Kumar, Mahendra; Lahey, Benjamin B.; Katz, Debra A.; Fernandez, Benny; Shaw, Jon; Campo, Ana; Nemeroff, Charles.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 26, No. 3, 01.01.2014, p. 262-270.

Research output: Contribution to journalArticle

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