Marked reduction in serotonergic activity in a sexually aggressive adolescent male

Adarsh M. Kumar, Mahendra Kumar, Benjamin B. Lahey, Debra A. Katz, Benny Fernandez, Jon A. Shaw, Ana Campo, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

Abstract

Serotonergic dysfunctions are implicated in conduct disorder, impulsivity, and aggression. Early adverse experiences increase the risk for these behaviors in adolescents. The authors investigated serotonergic activity in one adolescent male who experienced maternal abandonment and childhood abuse and exhibited severely aggressive sexual offenses. Platelet serotonin (5-HT) concentration, [14C]-5HT uptake kinetics, and plasma prolactin, cortisol response to D,L-fenfluramine (D,L-FEN) were measured. Results showed extremely low 5-HT concentration (2.960.7 ng/108 platelets), [14C]-5HT uptake rate (0.560.04 mM/min/ 107 platelets), undetectable Km and Vmax, and abnormally blunted prolactin, cortisol response to D,L-FEN. These abnormalities in this sexually aggressive adolescent may be a consequence of childhood abuse.

Original languageEnglish (US)
Pages (from-to)262-270
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume26
Issue number3
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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