Marked reduction in serotonergic activity in a sexually aggressive adolescent male

Adarsh Kumar, Mahendra Kumar, Benjamin B. Lahey, Debra A. Katz, Benny Fernandez, Jon Shaw, Ana Campo, Charles Nemeroff

Research output: Contribution to journalArticle


Serotonergic dysfunctions are implicated in conduct disorder, impulsivity, and aggression. Early adverse experiences increase the risk for these behaviors in adolescents. The authors investigated serotonergic activity in one adolescent male who experienced maternal abandonment and childhood abuse and exhibited severely aggressive sexual offenses. Platelet serotonin (5-HT) concentration, [14C]-5HT uptake kinetics, and plasma prolactin, cortisol response to D,L-fenfluramine (D,L-FEN) were measured. Results showed extremely low 5-HT concentration (2.960.7 ng/108 platelets), [14C]-5HT uptake rate (0.560.04 mM/min/ 107 platelets), undetectable Km and Vmax, and abnormally blunted prolactin, cortisol response to D,L-FEN. These abnormalities in this sexually aggressive adolescent may be a consequence of childhood abuse.

Original languageEnglish
Pages (from-to)262-270
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number3
StatePublished - Jan 1 2014


ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

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