Marked reduction in gonadal steroid hormone levels in rats treated neonatally with monosodium L-glutamate: Further evidence for disruption of hypothalamic-pituitary-gonadal axis regulation

Charles B. Nemeroff, Coral A. Lamartiniere, George A. Mason, Robert E. Squibb, John S. Hong, Stephen C. Bondy

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol-17β and testosterone were determined in adult rats that were treated in the neonatal period with monosodium L-glutamate (MSG) which has previously been shown to reliably produce destruction of arcuate nucleus perikarya. MSG-treated males had significantly smaller accessory sexual organs (seminal vesicles and ventral prostate) and testes and had significantly lower serum concentrations of FSH and testosterone than sex-matched controls. MSG-treated females had significantly lower serum concentrations of LH, FSH, and estradiol-17β. Prolactin levels in MSG-treated rats were no different than sex-matched controls. This marked reduction in gonadal steroid levels (↓68%) and inappropriately low gonadotropin levels further characterizes the deficit of feedback regulation in the hypothalamic-pituitary-gonadal axis in MSG-treated rats.

Original languageEnglish (US)
Pages (from-to)265-267
Number of pages3
JournalNeuroendocrinology
Volume33
Issue number5
DOIs
StatePublished - 1981
Externally publishedYes

Keywords

  • Estrogen
  • Gonadotropins
  • Monosodium glutamate
  • Prolactin
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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