Marked reduction in gonadal steroid hormone levels in rats treated neonatally with monosodium L-glutamate

Further evidence for disruption of hypothalamic-pituitary-gonadal axis regulation

Charles Nemeroff, C. A. Lamartiniere, G. A. Mason, R. E. Squibb, J. S. Hong, S. C. Bondy

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol-17β and testosterone were determined in adult rats that were treated in the neonatal period with monosodium L-glutamate (MSG) which has previously been shown to reliably produce destruction of arcuate nucleus perikarya. MSG-treated males had significantly smaller accessory sexual organs (seminal vesicles and ventral prostate) and testes and had significantly lower serum concentrations of FSH and testosterone than sex-matched controls. MSG-treated females had significantly lower serum concentrations of LH, FSH, and estradiol-17β. Prolactin levels in MSG-treated rats were no different than sex-matched controls. This marked reduction in gonadal steroid levels (↓68%) and inappropriately low gonadotropin levels further characterizes the deficit of feedback regulation in the hypothalamic-pituitary-gonadal axis in MSG-treated rats.

Original languageEnglish
Pages (from-to)265-267
Number of pages3
JournalNeuroendocrinology
Volume33
Issue number5
StatePublished - Nov 30 1981
Externally publishedYes

Fingerprint

Sodium Glutamate
Gonadal Steroid Hormones
Glutamic Acid
Follicle Stimulating Hormone
Luteinizing Hormone
Prolactin
Testosterone
Estradiol
Serum
Arcuate Nucleus of Hypothalamus
Seminal Vesicles
Gonadotropins
Testis
Prostate
Steroids

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Marked reduction in gonadal steroid hormone levels in rats treated neonatally with monosodium L-glutamate : Further evidence for disruption of hypothalamic-pituitary-gonadal axis regulation. / Nemeroff, Charles; Lamartiniere, C. A.; Mason, G. A.; Squibb, R. E.; Hong, J. S.; Bondy, S. C.

In: Neuroendocrinology, Vol. 33, No. 5, 30.11.1981, p. 265-267.

Research output: Contribution to journalArticle

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