Marked improvement of severe polyneuropathy associated with multifocal osteosclerotic myeloma following surgery, radiation, and chemotherapy

Francisco T. Rotta, Walter G. Bradley

Research output: Contribution to journalArticle

34 Scopus citations


We describe a patient with a 3 year history of progressive polyneuropathy that rendered him severely quadriparetic and bedridden. Work up revealed an IgG lambda monoclonal spike and multifocal osteosclerotic myeloma. Remarkable improvement followed combined treatment with surgical excision, radiation therapy, and chemotherapy using chlorambucil, danazol, and hydrocortisone. Hence, we believe that aggressive local therapy associated with systemic chemotherapy should be considered in severely affected patients with multifocal osteosclerotic myeloma and peripheral neuropathy.

Original languageEnglish (US)
Pages (from-to)1035-1037
Number of pages3
JournalMuscle and Nerve
Issue number8
StatePublished - Aug 2 1997



  • Osteosclerotic myeloma
  • Peripheral neuropathy
  • POEMS syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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