Marked for death

Kevin Petrie, Arthur Zelent

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


SUMOylation of PML-RARα oncoprotein has been linked to its arsenic-induced degradation and the therapeutic response in acute promyelocytic leukaemia. Two groups identify PML as an in vivo target of the RING finger ubiquitin E3 ligase RNF4, which specifically binds polySUMOylated PML and is essential for the arsenic-induced catabolism of both PML and PML-RARα.

Original languageEnglish (US)
Pages (from-to)507-509
Number of pages3
JournalNature Cell Biology
Issue number5
StatePublished - May 2008
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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