Marked for death

Kevin Petrie, Arthur Zelent

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

SUMOylation of PML-RARα oncoprotein has been linked to its arsenic-induced degradation and the therapeutic response in acute promyelocytic leukaemia. Two groups identify PML as an in vivo target of the RING finger ubiquitin E3 ligase RNF4, which specifically binds polySUMOylated PML and is essential for the arsenic-induced catabolism of both PML and PML-RARα.

Original languageEnglish (US)
Pages (from-to)507-509
Number of pages3
JournalNature Cell Biology
Volume10
Issue number5
DOIs
StatePublished - May 1 2008

ASJC Scopus subject areas

  • Cell Biology

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  • Cite this

    Petrie, K., & Zelent, A. (2008). Marked for death. Nature Cell Biology, 10(5), 507-509. https://doi.org/10.1038/ncb0508-507