Marked for death

Kevin Petrie, Arthur Z Zelent

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

SUMOylation of PML-RARα oncoprotein has been linked to its arsenic-induced degradation and the therapeutic response in acute promyelocytic leukaemia. Two groups identify PML as an in vivo target of the RING finger ubiquitin E3 ligase RNF4, which specifically binds polySUMOylated PML and is essential for the arsenic-induced catabolism of both PML and PML-RARα.

Original languageEnglish (US)
Pages (from-to)507-509
Number of pages3
JournalNature Cell Biology
Volume10
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

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Arsenic
Sumoylation
Acute Promyelocytic Leukemia
Ubiquitin-Protein Ligases
Oncogene Proteins
Therapeutics

ASJC Scopus subject areas

  • Cell Biology

Cite this

Petrie, K., & Zelent, A. Z. (2008). Marked for death. Nature Cell Biology, 10(5), 507-509. https://doi.org/10.1038/ncb0508-507

Marked for death. / Petrie, Kevin; Zelent, Arthur Z.

In: Nature Cell Biology, Vol. 10, No. 5, 05.2008, p. 507-509.

Research output: Contribution to journalArticle

Petrie, K & Zelent, AZ 2008, 'Marked for death', Nature Cell Biology, vol. 10, no. 5, pp. 507-509. https://doi.org/10.1038/ncb0508-507
Petrie K, Zelent AZ. Marked for death. Nature Cell Biology. 2008 May;10(5):507-509. https://doi.org/10.1038/ncb0508-507
Petrie, Kevin ; Zelent, Arthur Z. / Marked for death. In: Nature Cell Biology. 2008 ; Vol. 10, No. 5. pp. 507-509.
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