Mapping the functional connectivity of anterior cingulate cortex

Daniel S. Margulies, A. M C Kelly, Lucina Q Uddin, Bharat B. Biswal, F. Xavier Castellanos, Michael P. Milham

Research output: Contribution to journalArticle

477 Citations (Scopus)

Abstract

Anterior cingulate cortex (ACC) is a nexus of information processing and regulation in the brain. Reflecting this central role, ACC is structurally and functionally heterogeneous, a fact long appreciated in studies of non-human primates. Human neuroimaging studies also recognize this functional heterogeneity, with meta-analyses and task-based studies demonstrating the existence of motor, cognitive and affective subdivisions. In contrast to task-based approaches, examinations of resting-state functional connectivity enable the characterization of task-independent patterns of correlated activity. In a novel approach to understanding ACC functional segregation, we systematically mapped ACC functional connectivity during rest. We examined patterns of functional connectivity for 16 seed ROIs systematically placed throughout caudal, rostral, and subgenual ACC in each hemisphere. First, our data support the commonly observed rostral/caudal distinction, but also suggest the existence of a dorsal/ventral functional distinction. For each of these distinctions, more fine-grained patterns of differentiation were observed than commonly appreciated in human imaging studies. Second, we demonstrate the presence of negatively predicted relationships between distinct ACC functional networks. In particular, we highlight negative relationships between rostral ACC-based affective networks (including the "default mode network") and dorsal-caudal ACC-based frontoparietal attention networks. Finally, interhemispheric activations were more strongly correlated between homologous regions than in non-homologous regions. We discuss the implications of our work for understanding ACC function and potential applications to clinical populations.

Original languageEnglish (US)
Pages (from-to)579-588
Number of pages10
JournalNeuroImage
Volume37
Issue number2
DOIs
StatePublished - Aug 15 2007
Externally publishedYes

Fingerprint

Gyrus Cinguli
Automatic Data Processing
Neuroimaging
Primates
Meta-Analysis
Seeds
Brain

Keywords

  • Anticorrelation
  • Brain mapping
  • Intrinsic functional activity
  • Resting state networks

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Margulies, D. S., Kelly, A. M. C., Uddin, L. Q., Biswal, B. B., Castellanos, F. X., & Milham, M. P. (2007). Mapping the functional connectivity of anterior cingulate cortex. NeuroImage, 37(2), 579-588. https://doi.org/10.1016/j.neuroimage.2007.05.019

Mapping the functional connectivity of anterior cingulate cortex. / Margulies, Daniel S.; Kelly, A. M C; Uddin, Lucina Q; Biswal, Bharat B.; Castellanos, F. Xavier; Milham, Michael P.

In: NeuroImage, Vol. 37, No. 2, 15.08.2007, p. 579-588.

Research output: Contribution to journalArticle

Margulies, DS, Kelly, AMC, Uddin, LQ, Biswal, BB, Castellanos, FX & Milham, MP 2007, 'Mapping the functional connectivity of anterior cingulate cortex', NeuroImage, vol. 37, no. 2, pp. 579-588. https://doi.org/10.1016/j.neuroimage.2007.05.019
Margulies DS, Kelly AMC, Uddin LQ, Biswal BB, Castellanos FX, Milham MP. Mapping the functional connectivity of anterior cingulate cortex. NeuroImage. 2007 Aug 15;37(2):579-588. https://doi.org/10.1016/j.neuroimage.2007.05.019
Margulies, Daniel S. ; Kelly, A. M C ; Uddin, Lucina Q ; Biswal, Bharat B. ; Castellanos, F. Xavier ; Milham, Michael P. / Mapping the functional connectivity of anterior cingulate cortex. In: NeuroImage. 2007 ; Vol. 37, No. 2. pp. 579-588.
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