Mapping of the gene for hormone sensitive lipase (LIPE) to chromosome 19q13.1 → q13.2

R. C. Levitt, Z. Liu, N. Nouri, D. A. Meyers, B. Brandriff, H. M. Mohrenweiser

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Free fatty acids are the major source of fuel for mammals, and hormone sensitive lipase (LIPE) plays a critical role in lipid metabolism by mobilizing free fatty acids from stored triglycerides. We have identified and sequenced a partial cDNA for LIPE. Cosmids were identified by hybridization and mapped to 19q13.1 → q13.2 by FISH. Direct sequence analysis of a 1 kb segment of cosmid 26710 identifies a dinucleotide repeat in an intron upstream of exon 8 of human LIPE. This marker was heterozygous 82 % of the time with 12 alleles (166-190 bp) detected in 122 chromosomes. The most likely order for this gene is: qter-[D19S178/LIPE]-(3 cM)-D19S47-(1 cM)-D19S190-RYR1-cen.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalCytogenetics and cell genetics
Volume69
Issue number3-4
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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