Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints

Florence Pedeutour, Sandra Merscher, Elisabeth Durieux, Kate Montgomery, Kenneth Krauter, Jean Pascal Clevy, Gisèle Barcelo, Raju Kucherlapati, Patrick Gaudray, Claude Turc-Carel

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The consistent involvement of the region 12q13-q15 in numerous human tumors speaks in favor of the presence of genes that may contribute to oncogenesis. Mapping genes within this region of chromosome 12 is a necessary step toward the identification of those that play a role in this process. We have undertaken a multiplex analysis using translocation breakpoint mapping to order from the centromere to the telomere a series of 24 loci from the region 12q12-q22. Thirteen adipose tissue tumors with seven different chromosome changes involving the long arm of chromosome 12 (12q) were used. Since most of these loci are genes or anonymous DNA segments largely available to the scientific community, this map should be useful for investigation of genetic disorders associated with chromosome 12q. While these breakpoints were used as natural landmarks to order groups of loci, this work has positioned them more accurately, leading to a better chromosomal definition of the translocations than the one derived from standard cytogenetic studies.

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
JournalGenomics
Volume22
Issue number3
DOIs
StatePublished - Aug 1994

ASJC Scopus subject areas

  • Genetics

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    Pedeutour, F., Merscher, S., Durieux, E., Montgomery, K., Krauter, K., Clevy, J. P., Barcelo, G., Kucherlapati, R., Gaudray, P., & Turc-Carel, C. (1994). Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints. Genomics, 22(3), 512-518. https://doi.org/10.1006/geno.1994.1424