Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints

F. Pedeutour, Sandra M Merscher-gomez, E. Durieux, K. Montgomery, K. Krauter, J. P. Clevy -, G. Barcelo, R. Kucherlapati, P. Gaudray, C. Turc-Carel

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The consistent involvement of the region 12q13-q15 in numerous human tumors speaks in favor of the presence of genes that may contribute to oncogenesis. Mapping genes within this region of chromosome 12 is a necessary step toward the identification of those that play a role in this process. We have undertaken a multiplex analysis using translocation breakpoint mapping to order from the centromere to the telomere a series of 24 loci from the region 12q12-q22. Thirteen adipose tissue tumors with seven different chromosome changes involving the long arm of chromosome 12 (12q) were used. Since most of these loci are genes or anonymous DNA segments largely available to the scientific community, this map should be useful for investigation of genetic disorders associated with chromosome 12q. While these breakpoints were used as natural landmarks to order groups of loci, this work has positioned them more accurately, leading to a better chromosomal definition of the translocations than the one derived from standard cytogenetic studies.

Original languageEnglish
Pages (from-to)512-518
Number of pages7
JournalGenomics
Volume22
Issue number3
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 12
Chromosomes
Genetic Translocation
Inborn Genetic Diseases
Centromere
Chromosome Mapping
Telomere
Cytogenetics
Genes
Adipose Tissue
Neoplasms
Carcinogenesis
DNA

ASJC Scopus subject areas

  • Genetics

Cite this

Pedeutour, F., Merscher-gomez, S. M., Durieux, E., Montgomery, K., Krauter, K., Clevy -, J. P., ... Turc-Carel, C. (1994). Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints. Genomics, 22(3), 512-518. https://doi.org/10.1006/geno.1994.1424

Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints. / Pedeutour, F.; Merscher-gomez, Sandra M; Durieux, E.; Montgomery, K.; Krauter, K.; Clevy -, J. P.; Barcelo, G.; Kucherlapati, R.; Gaudray, P.; Turc-Carel, C.

In: Genomics, Vol. 22, No. 3, 01.01.1994, p. 512-518.

Research output: Contribution to journalArticle

Pedeutour, F, Merscher-gomez, SM, Durieux, E, Montgomery, K, Krauter, K, Clevy -, JP, Barcelo, G, Kucherlapati, R, Gaudray, P & Turc-Carel, C 1994, 'Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints', Genomics, vol. 22, no. 3, pp. 512-518. https://doi.org/10.1006/geno.1994.1424
Pedeutour F, Merscher-gomez SM, Durieux E, Montgomery K, Krauter K, Clevy - JP et al. Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints. Genomics. 1994 Jan 1;22(3):512-518. https://doi.org/10.1006/geno.1994.1424
Pedeutour, F. ; Merscher-gomez, Sandra M ; Durieux, E. ; Montgomery, K. ; Krauter, K. ; Clevy -, J. P. ; Barcelo, G. ; Kucherlapati, R. ; Gaudray, P. ; Turc-Carel, C. / Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints. In: Genomics. 1994 ; Vol. 22, No. 3. pp. 512-518.
@article{866b8cb91c6843b18fbda54329b7d340,
title = "Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints",
abstract = "The consistent involvement of the region 12q13-q15 in numerous human tumors speaks in favor of the presence of genes that may contribute to oncogenesis. Mapping genes within this region of chromosome 12 is a necessary step toward the identification of those that play a role in this process. We have undertaken a multiplex analysis using translocation breakpoint mapping to order from the centromere to the telomere a series of 24 loci from the region 12q12-q22. Thirteen adipose tissue tumors with seven different chromosome changes involving the long arm of chromosome 12 (12q) were used. Since most of these loci are genes or anonymous DNA segments largely available to the scientific community, this map should be useful for investigation of genetic disorders associated with chromosome 12q. While these breakpoints were used as natural landmarks to order groups of loci, this work has positioned them more accurately, leading to a better chromosomal definition of the translocations than the one derived from standard cytogenetic studies.",
author = "F. Pedeutour and Merscher-gomez, {Sandra M} and E. Durieux and K. Montgomery and K. Krauter and {Clevy -}, {J. P.} and G. Barcelo and R. Kucherlapati and P. Gaudray and C. Turc-Carel",
year = "1994",
month = "1",
day = "1",
doi = "10.1006/geno.1994.1424",
language = "English",
volume = "22",
pages = "512--518",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints

AU - Pedeutour, F.

AU - Merscher-gomez, Sandra M

AU - Durieux, E.

AU - Montgomery, K.

AU - Krauter, K.

AU - Clevy -, J. P.

AU - Barcelo, G.

AU - Kucherlapati, R.

AU - Gaudray, P.

AU - Turc-Carel, C.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The consistent involvement of the region 12q13-q15 in numerous human tumors speaks in favor of the presence of genes that may contribute to oncogenesis. Mapping genes within this region of chromosome 12 is a necessary step toward the identification of those that play a role in this process. We have undertaken a multiplex analysis using translocation breakpoint mapping to order from the centromere to the telomere a series of 24 loci from the region 12q12-q22. Thirteen adipose tissue tumors with seven different chromosome changes involving the long arm of chromosome 12 (12q) were used. Since most of these loci are genes or anonymous DNA segments largely available to the scientific community, this map should be useful for investigation of genetic disorders associated with chromosome 12q. While these breakpoints were used as natural landmarks to order groups of loci, this work has positioned them more accurately, leading to a better chromosomal definition of the translocations than the one derived from standard cytogenetic studies.

AB - The consistent involvement of the region 12q13-q15 in numerous human tumors speaks in favor of the presence of genes that may contribute to oncogenesis. Mapping genes within this region of chromosome 12 is a necessary step toward the identification of those that play a role in this process. We have undertaken a multiplex analysis using translocation breakpoint mapping to order from the centromere to the telomere a series of 24 loci from the region 12q12-q22. Thirteen adipose tissue tumors with seven different chromosome changes involving the long arm of chromosome 12 (12q) were used. Since most of these loci are genes or anonymous DNA segments largely available to the scientific community, this map should be useful for investigation of genetic disorders associated with chromosome 12q. While these breakpoints were used as natural landmarks to order groups of loci, this work has positioned them more accurately, leading to a better chromosomal definition of the translocations than the one derived from standard cytogenetic studies.

UR - http://www.scopus.com/inward/record.url?scp=0028100890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028100890&partnerID=8YFLogxK

U2 - 10.1006/geno.1994.1424

DO - 10.1006/geno.1994.1424

M3 - Article

VL - 22

SP - 512

EP - 518

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 3

ER -