Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI)

Andrew A Maudsley, C. Domenig, Varan Govind, A. Darkazanli, C. Studholme, Kristopher Arheart, C. Bloomer

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Distributions of proton MR-detected metabolites have been mapped throughout the brain in a group of normal subjects using a volumetric MR spectroscopic imaging (MRSI) acquisition with an interleaved water reference. Data were processed with intensity and spatial normalization to enable voxel-based analysis methods to be applied across a group of subjects. Results demonstrate significant regional, tissue, and gender-dependent variations of brain metabolite concentrations, and variations of these distributions with normal aging. The greatest alteration of metabolites with age was observed for white-matter choline and creatine. An example of the utility of the normative metabolic reference information is then demonstrated for analysis of data acquired from a subject who suffered a traumatic brain injury. This study demonstrates the ability to obtain proton spectra from a wide region of the brain and to apply fully automated processing methods. The resultant data provide a normative reference for subsequent utilization for studies of brain injury and disease.

Original languageEnglish
Pages (from-to)548-559
Number of pages12
JournalMagnetic Resonance in Medicine
Volume61
Issue number3
DOIs
StatePublished - Mar 1 2009

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Brain Mapping
Protons
Brain
Creatine
Normal Distribution
Brain Diseases
Choline
Brain Injuries
Water

Keywords

  • Age
  • Brain
  • Data processing
  • Metabolite distributions
  • Proton MR spectroscopic imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). / Maudsley, Andrew A; Domenig, C.; Govind, Varan; Darkazanli, A.; Studholme, C.; Arheart, Kristopher; Bloomer, C.

In: Magnetic Resonance in Medicine, Vol. 61, No. 3, 01.03.2009, p. 548-559.

Research output: Contribution to journalArticle

Maudsley, Andrew A ; Domenig, C. ; Govind, Varan ; Darkazanli, A. ; Studholme, C. ; Arheart, Kristopher ; Bloomer, C. / Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). In: Magnetic Resonance in Medicine. 2009 ; Vol. 61, No. 3. pp. 548-559.
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