Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI)

Andrew A. Maudsley, C. Domenig, V. Govind, A. Darkazanli, C. Studholme, K. Arheart, C. Bloomer

Research output: Contribution to journalArticlepeer-review

187 Scopus citations


Distributions of proton MR-detected metabolites have been mapped throughout the brain in a group of normal subjects using a volumetric MR spectroscopic imaging (MRSI) acquisition with an interleaved water reference. Data were processed with intensity and spatial normalization to enable voxel-based analysis methods to be applied across a group of subjects. Results demonstrate significant regional, tissue, and gender-dependent variations of brain metabolite concentrations, and variations of these distributions with normal aging. The greatest alteration of metabolites with age was observed for white-matter choline and creatine. An example of the utility of the normative metabolic reference information is then demonstrated for analysis of data acquired from a subject who suffered a traumatic brain injury. This study demonstrates the ability to obtain proton spectra from a wide region of the brain and to apply fully automated processing methods. The resultant data provide a normative reference for subsequent utilization for studies of brain injury and disease.

Original languageEnglish (US)
Pages (from-to)548-559
Number of pages12
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Mar 2009


  • Age
  • Brain
  • Data processing
  • Metabolite distributions
  • Proton MR spectroscopic imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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