@article{89df7e3e792e4145ae7ac92943d55745,
title = "Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans",
abstract = "An underlying complex genetic susceptibility exists in multiple sclerosis (MS), and an association with the HLA-DRB1*1501-DQB1*0602 haplotype has been repeatedly demonstrated in high-risk (northern European) populations. It is unknown whether the effect is explained by the HLA-DRB1 or the HLA-DQB1 gene within the susceptibility haplotype, which are in strong linkage disequilibrium (LD). African populations are characterized by greater haplotypic diversity and distinct patterns of LD compared with northern Europeans. To better localize the HLA gene responsible for MS susceptibility, case-control and family-based association studies were performed for DRB1 and DQB1 loci in a large and well-characterized African American data set. A selective association with HLA-DRB1*15 was revealed, indicating a primary role for the DRB1 locus in MS independent of DQB1*0602. This finding is unlikely to be solely explained by admixture, since a substantial proportion of the susceptibility chromosomes from African American patients with MS displayed haplotypes consistent with an African origin.",
author = "Oksenberg, {Jorge R.} and Barcellos, {Lisa F.} and Cree, {Bruce A.C.} and Baranzini, {Sergio E.} and Bugawan, {Teodorica L.} and Omar Khan and Lincoln, {Robin R.} and Amy Swerdlin and Emmanuel Mignot and Ling Lin and Douglas Goodin and Erlich, {Henry A.} and Silke Schmidt and Glenys Thomson and Reich, {David E.} and Pericak-Vance, {Margaret A.} and Haines, {Jonathan L.} and Hauser, {Stephen L.}",
note = "Funding Information: We are grateful to the patients with MS and their families, for participating in this study, and to Mr. M. Williams, for his support. We thank S. Mack, for fruitful discussions; and P. Bucher, A. Tselis, C. Caon, W. Ching, E. Sonenvirth, and A. Seligman, for recruitment of patients to the study and for expert technical help. We also thank R. Hendrickson for database development, G. Artim for programming assistance, and R. Single for assisting with 13th International Histocompatibility Workshop data queries. This work was funded by National Institutes of Health grants NS 46297, NS 26799, and GM35326; by National Multiple Sclerosis Society grant RG3060; and by the Nancy Davis Foundation. L.F.B. is a UCSF-BIRCWH Scholar. B.A.C.C. is a National Multiple Sclerosis Society postdoctoral fellow. ",
year = "2004",
month = jan,
doi = "10.1086/380997",
language = "English (US)",
volume = "74",
pages = "160--167",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "1",
}