Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011)

P. J. Touboul, M. G. Hennerici, S. Meairs, H. Adams, P. Amarenco, N. Bornstein, L. Csiba, M. Desvarieux, S. Ebrahim, R. Hernandez Hernandez, M. Jaff, S. Kownator, T. Naqvi, P. Prati, Tatjana Rundek, M. Sitzer, U. Schminke, J. C. Tardif, A. Taylor, E. VicautK. S. Woo

Research output: Contribution to journalArticle

558 Citations (Scopus)

Abstract

Intima-media thickness (IMT) provides a surrogate end point of cardiovascular outcomes in clinical trials evaluating the efficacy of cardiovascular risk factor modification. Carotid artery plaque further adds to the cardiovascular risk assessment. It is defined as a focal structure that encroaches into the arterial lumen of at least 0.5 mm or 50% of the surrounding IMT value or demonstrates a thickness >1.5 mm as measured from the media-adventitia interface to the intima-lumen interface. The scientific basis for use of IMT in clinical trials and practice includes ultrasound physics, technical and disease-related principles as well as best practice on the performance, interpretation and documentation of study results. Comparison of IMT results obtained from epidemiological and interventional studies around the world relies on harmonization on approaches to carotid image acquisition and analysis. This updated consensus document delineates further criteria to distinguish early atherosclerotic plaque formation from thickening of IMT. Standardized methods will foster homogenous data collection and analysis, improve the power of randomized clinical trials incorporating IMT and plaque measurements and facilitate the merging of large databases for meta-analyses. IMT results are applied to individual patients as an integrated assessment of cardiovascular risk factors. However, this document recommends against serial monitoring in individual patients.

Original languageEnglish
Pages (from-to)290-296
Number of pages7
JournalCerebrovascular Diseases
Volume34
Issue number4
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

Fingerprint

Carotid Intima-Media Thickness
Clinical Trials
Adventitia
Carotid Stenosis
Physics
Atherosclerotic Plaques
Practice Guidelines
Documentation
Meta-Analysis
Epidemiologic Studies
Randomized Controlled Trials
Biomarkers
Databases

Keywords

  • Carotid disease
  • Carotid plaque
  • Intima-media thickness
  • Randomized clinical trials
  • Reference values
  • Vascular ultrasound

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Touboul, P. J., Hennerici, M. G., Meairs, S., Adams, H., Amarenco, P., Bornstein, N., ... Woo, K. S. (2012). Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). Cerebrovascular Diseases, 34(4), 290-296. https://doi.org/10.1159/000343145

Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). / Touboul, P. J.; Hennerici, M. G.; Meairs, S.; Adams, H.; Amarenco, P.; Bornstein, N.; Csiba, L.; Desvarieux, M.; Ebrahim, S.; Hernandez Hernandez, R.; Jaff, M.; Kownator, S.; Naqvi, T.; Prati, P.; Rundek, Tatjana; Sitzer, M.; Schminke, U.; Tardif, J. C.; Taylor, A.; Vicaut, E.; Woo, K. S.

In: Cerebrovascular Diseases, Vol. 34, No. 4, 01.11.2012, p. 290-296.

Research output: Contribution to journalArticle

Touboul, PJ, Hennerici, MG, Meairs, S, Adams, H, Amarenco, P, Bornstein, N, Csiba, L, Desvarieux, M, Ebrahim, S, Hernandez Hernandez, R, Jaff, M, Kownator, S, Naqvi, T, Prati, P, Rundek, T, Sitzer, M, Schminke, U, Tardif, JC, Taylor, A, Vicaut, E & Woo, KS 2012, 'Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011)', Cerebrovascular Diseases, vol. 34, no. 4, pp. 290-296. https://doi.org/10.1159/000343145
Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N et al. Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). Cerebrovascular Diseases. 2012 Nov 1;34(4):290-296. https://doi.org/10.1159/000343145
Touboul, P. J. ; Hennerici, M. G. ; Meairs, S. ; Adams, H. ; Amarenco, P. ; Bornstein, N. ; Csiba, L. ; Desvarieux, M. ; Ebrahim, S. ; Hernandez Hernandez, R. ; Jaff, M. ; Kownator, S. ; Naqvi, T. ; Prati, P. ; Rundek, Tatjana ; Sitzer, M. ; Schminke, U. ; Tardif, J. C. ; Taylor, A. ; Vicaut, E. ; Woo, K. S. / Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). In: Cerebrovascular Diseases. 2012 ; Vol. 34, No. 4. pp. 290-296.
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