Abstract
Background. We reviewed management of the cervical lymph nodes in patients with Merkel cell carcinoma (MCC) of the head and neck. Methods. Records of 15 patients with MCC of the head and neck area were evaluated for the type of surgical treatment, including wide local excision, sentinel lymph node (SLN) biopsy, neck dissection, postoperative radiation therapy, and clinical outcomes. Results. Median follow-up was 24 months (range, 5-84 months). Ten patients were treated with wide local excision plus SLN, with or without neck dissection. Five patients were treated with wide local excision only or wide local excision plus neck dissection. One patient died of distant metastases (7%), and 14 patients remain alive (93%), over a mean follow-up of 24 months. Conclusion. Wide excision and SLN biopsy for primary MCC with N0 neck is feasible for early-stage, previously untreated lesions. SLN biopsy was helpful in determining the nodal levels to be dissected or irradiated.
| Original language | English |
|---|---|
| Pages (from-to) | 1559-1565 |
| Number of pages | 7 |
| Journal | Head and Neck |
| Volume | 30 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2008 |
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Keywords
- Immunohistochemistry
- Merkel cell carcinoma
- Neck dissection
- Sentinel lymph node biopsy
- Skin carcinoma
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Management of the neck in Merkel cell carcinoma of the head and neck : University of Miami experience. / Shnayder, Yelizaveta; Weed, Donald; Arnold, David; Gomez-Fernandez, Carmen; Bared, Anthony; Goodwin, W. Jarrard; Civantos, Francisco.
In: Head and Neck, Vol. 30, No. 12, 01.12.2008, p. 1559-1565.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Management of the neck in Merkel cell carcinoma of the head and neck
T2 - University of Miami experience
AU - Shnayder, Yelizaveta
AU - Weed, Donald
AU - Arnold, David
AU - Gomez-Fernandez, Carmen
AU - Bared, Anthony
AU - Goodwin, W. Jarrard
AU - Civantos, Francisco
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Background. We reviewed management of the cervical lymph nodes in patients with Merkel cell carcinoma (MCC) of the head and neck. Methods. Records of 15 patients with MCC of the head and neck area were evaluated for the type of surgical treatment, including wide local excision, sentinel lymph node (SLN) biopsy, neck dissection, postoperative radiation therapy, and clinical outcomes. Results. Median follow-up was 24 months (range, 5-84 months). Ten patients were treated with wide local excision plus SLN, with or without neck dissection. Five patients were treated with wide local excision only or wide local excision plus neck dissection. One patient died of distant metastases (7%), and 14 patients remain alive (93%), over a mean follow-up of 24 months. Conclusion. Wide excision and SLN biopsy for primary MCC with N0 neck is feasible for early-stage, previously untreated lesions. SLN biopsy was helpful in determining the nodal levels to be dissected or irradiated.
AB - Background. We reviewed management of the cervical lymph nodes in patients with Merkel cell carcinoma (MCC) of the head and neck. Methods. Records of 15 patients with MCC of the head and neck area were evaluated for the type of surgical treatment, including wide local excision, sentinel lymph node (SLN) biopsy, neck dissection, postoperative radiation therapy, and clinical outcomes. Results. Median follow-up was 24 months (range, 5-84 months). Ten patients were treated with wide local excision plus SLN, with or without neck dissection. Five patients were treated with wide local excision only or wide local excision plus neck dissection. One patient died of distant metastases (7%), and 14 patients remain alive (93%), over a mean follow-up of 24 months. Conclusion. Wide excision and SLN biopsy for primary MCC with N0 neck is feasible for early-stage, previously untreated lesions. SLN biopsy was helpful in determining the nodal levels to be dissected or irradiated.
KW - Immunohistochemistry
KW - Merkel cell carcinoma
KW - Neck dissection
KW - Sentinel lymph node biopsy
KW - Skin carcinoma
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UR - http://www.scopus.com/inward/citedby.url?scp=57349140837&partnerID=8YFLogxK
U2 - 10.1002/hed.20899
DO - 10.1002/hed.20899
M3 - Article
C2 - 18767173
AN - SCOPUS:57349140837
VL - 30
SP - 1559
EP - 1565
JO - Head and Neck
JF - Head and Neck
SN - 1043-3074
IS - 12
ER -