Management of pigmented conjunctival lesions

Patrick Oellers, Carol Karp

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Pigmented conjunctival lesions primarily include melanoma, nevus, primary acquired melanosis (PAM), and complexion-associated melanosis. The incidence of conjunctival malignant melanoma (CMM) has significantly increased in the USA and Europe over the years, and it carries a very serious risk for metastasis and melanomarelated death. Conjunctival melanoma can arise de novo or from precursor lesions, nevus, and PAM. PAM is histologically separated into two distinct forms: PAM with atypia and without atypia. PAM with severe atypia progresses to malignant melanoma in up to 50% of cases and PAM without atypia virtually never progresses. Nevus is a benign melanocytic tumor that only rarely undergoes malignant transformation. Complexion-associated melanosis is frequently seen in more darkly pigmented individuals and does not progress to melanoma, although it can become very large. A detailed literature review on the various pigmented conjunctival lesions together with a schematic approach to diagnosis and management is presented.

Original languageEnglish (US)
Pages (from-to)251-263
Number of pages13
JournalOcular Surface
Volume10
Issue number4
DOIs
StatePublished - 2012

Fingerprint

Melanosis
Melanoma
Nevus
Nevi and Melanomas
Neoplasm Metastasis
Incidence

Keywords

  • BRAF
  • Complexion-associated melanosis
  • Conjunctival melanosis
  • Genetics
  • Melanoma
  • Nevus
  • Notouch surgery
  • Ocular surface
  • Pigmented lesion
  • Primary acquired melanosis (PAM)
  • Topical chemotherapy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Management of pigmented conjunctival lesions. / Oellers, Patrick; Karp, Carol.

In: Ocular Surface, Vol. 10, No. 4, 2012, p. 251-263.

Research output: Contribution to journalReview article

Oellers, Patrick ; Karp, Carol. / Management of pigmented conjunctival lesions. In: Ocular Surface. 2012 ; Vol. 10, No. 4. pp. 251-263.
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