Management of paranasal sinus malignancy

Terry A. Day, Ricardo A. Beas, Rodney J. Schlosser, Bradford A. Woodworth, Julio Barredo, Anand K. Sharma, M. Boyd Gillespie

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Malignancies of the nasal cavity and paranasal sinuses represent a wide spectrum of histologies, tissues of origin, and anatomic primary sites. The inherent difficulty in generalizing treatment approaches is obvious, given the numerous variables associated with the broadly-based term, paranasal sinus malignancy (PNSCa). Nevertheless, the majority of epithelial and salivary malignancies of this region (ie, squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, sinonasal undifferentiated carcinoma, and esthesioneuroblastoma) require surgical intervention as part of any treatment regimen. Recent trends have broadened the indications for chemotherapeutic and radiotherapeutic options in the management of advanced PNSCa. Nonepithelial malignancies, including the wide variety of sarcomas arising in this region, most commonly require multimodality treatment including chemotherapy, radiation, and/or surgery for definitive treatment. Moreover, the proximity of the nasal cavity and paranasal sinuses to structures including the orbit, dura, brain, cranial nerves, and carotid arteries mandates careful radiologic and neurologic evaluations throughout the course of the disease. Surgical advances now permit complex tumor removal and reconstruction surrounding these structures resulting in functional and cosmetic improvements when compared to earlier techniques. However, additional clinical trials are necessary to systematically evaluate the locoregional control, organ-preservation strategies, and survival related to the variety of treatments currently available.

Original languageEnglish
Pages (from-to)3-18
Number of pages16
JournalCurrent Treatment Options in Oncology
Volume6
Issue number1
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Paranasal Sinuses
Nasal Cavity
Neoplasms
Olfactory Esthesioneuroblastoma
Organ Preservation
Therapeutics
Tissue Survival
Adenoid Cystic Carcinoma
Cranial Nerves
Orbit
Carotid Arteries
Cosmetics
Sarcoma
Nervous System
Squamous Cell Carcinoma
Histology
Adenocarcinoma
Clinical Trials
Radiation
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Day, T. A., Beas, R. A., Schlosser, R. J., Woodworth, B. A., Barredo, J., Sharma, A. K., & Gillespie, M. B. (2005). Management of paranasal sinus malignancy. Current Treatment Options in Oncology, 6(1), 3-18.

Management of paranasal sinus malignancy. / Day, Terry A.; Beas, Ricardo A.; Schlosser, Rodney J.; Woodworth, Bradford A.; Barredo, Julio; Sharma, Anand K.; Gillespie, M. Boyd.

In: Current Treatment Options in Oncology, Vol. 6, No. 1, 01.01.2005, p. 3-18.

Research output: Contribution to journalArticle

Day, TA, Beas, RA, Schlosser, RJ, Woodworth, BA, Barredo, J, Sharma, AK & Gillespie, MB 2005, 'Management of paranasal sinus malignancy', Current Treatment Options in Oncology, vol. 6, no. 1, pp. 3-18.
Day TA, Beas RA, Schlosser RJ, Woodworth BA, Barredo J, Sharma AK et al. Management of paranasal sinus malignancy. Current Treatment Options in Oncology. 2005 Jan 1;6(1):3-18.
Day, Terry A. ; Beas, Ricardo A. ; Schlosser, Rodney J. ; Woodworth, Bradford A. ; Barredo, Julio ; Sharma, Anand K. ; Gillespie, M. Boyd. / Management of paranasal sinus malignancy. In: Current Treatment Options in Oncology. 2005 ; Vol. 6, No. 1. pp. 3-18.
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