Management of infertility in klinefelter syndrome

Ranjith Ramasamy, Affan Zafar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Klinefelter syndrome (KS) is a relatively common disorder with significant morbidity. Symptomatic adolescents with hypogonadal KS can be treated with testosterone supplementation therapy for androgen deficiency and concurrent human chorionic gonadotropin (hCG) to preserve fertility. Invasive biopsies and cryopreservation are not recommended in adolescents because they have significant negative effects and provide no advantage compared to delaying such procedures until adulthood when fertility is desired. For adults who have KS and desire fertility, the recommendation is medical therapy to optimize intratesticular testosterone, if the patient has a low serum testosterone level, followed by microdissection testicular sperm extraction (TESE) and pregnancy by intracytoplasmic sperm injection (ICSI). The management of fertility in adults with KS is well established with good pregnancy outcomes.

Original languageEnglish (US)
Title of host publicationMale Infertility
Subtitle of host publicationA Clinical Approach
PublisherSpringer India
Pages135-144
Number of pages10
ISBN (Electronic)9788132236047
ISBN (Print)9788132236023
DOIs
StatePublished - Jan 1 2016

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Klinefelter Syndrome
Infertility
Fertility
Testosterone
Microdissection
Intracytoplasmic Sperm Injections
Cryopreservation
Chorionic Gonadotropin
Pregnancy Outcome
Androgens
Spermatozoa
Morbidity
Biopsy
Pregnancy
Therapeutics
Serum

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

Cite this

Ramasamy, R., & Zafar, A. (2016). Management of infertility in klinefelter syndrome. In Male Infertility: A Clinical Approach (pp. 135-144). Springer India. https://doi.org/10.1007/978-81-322-3604-7_8

Management of infertility in klinefelter syndrome. / Ramasamy, Ranjith; Zafar, Affan.

Male Infertility: A Clinical Approach. Springer India, 2016. p. 135-144.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ramasamy, R & Zafar, A 2016, Management of infertility in klinefelter syndrome. in Male Infertility: A Clinical Approach. Springer India, pp. 135-144. https://doi.org/10.1007/978-81-322-3604-7_8
Ramasamy R, Zafar A. Management of infertility in klinefelter syndrome. In Male Infertility: A Clinical Approach. Springer India. 2016. p. 135-144 https://doi.org/10.1007/978-81-322-3604-7_8
Ramasamy, Ranjith ; Zafar, Affan. / Management of infertility in klinefelter syndrome. Male Infertility: A Clinical Approach. Springer India, 2016. pp. 135-144
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