Management of hepatocellular carcinoma with transarterial chemoembolization in the era of systemic targeted therapy

Riccardo Lencioni

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

The clinical management of hepatocellular carcinoma (HCC) is often complicated by poor liver function. Treatment options for intermediate- and advanced-stage disease are limited. Transcatheter arterial chemoembolization (TACE) is an effective first-line therapy for intermediate-stage HCC. By interrupting blood flow to the tumor and administering concentrated chemotherapy locoregionally, TACE induces necrosis at the tumor site, but may create conditions that permit or encourage angiogenesis and recurrence of the tumor. Combination of TACE with new targeted agents may be an effective way to treat intermediate-stage HCC, particularly in higher risk patients. Because of the efficacy and safety of sorafenib-the first systemic therapy to show significant clinical benefit in advanced HCC-there is great interest in its potential use in combination with existing treatment modalities. The synergistic combination of TACE plus sorafenib represents a promising opportunity for tumor control.

Original languageEnglish (US)
Pages (from-to)216-224
Number of pages9
JournalCritical Reviews in Oncology/Hematology
Volume83
Issue number2
DOIs
StatePublished - Aug 1 2012

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Keywords

  • Hepatocellular carcinoma
  • Multikinase inhibitors
  • Sorafenib
  • Transarterial chemoembolization

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Geriatrics and Gerontology

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