Management of HCV infection and liver transplantation

Thomas D. Schiano, Paul Martin

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

A major challenge facing liver transplant recipients and their physicians is recurrence of hepatitis C virus infection following otherwise technically successful liver transplantation. Recurrent infection leads to diminished graft and patient survival. Although a number or predictors of severe recurrence have been identified, no definitive strategy has been developed to prevent recurrence. Generally the tempo of hepatitis C recurrence is gauged by serial liver biopsies with the decision to intervene with antiviral therapy based on local philosophy and expertise. Treating hepatitis C in this population has a number of major challenges including diminished patient tolerance for side-effects as well as managing the patient's immunesuppression. However sustained viral responses are possible with the potential to reduce the impact of recurrent hepatitis on the graft. However recurrent hepatitis C virus infection will remain the most frequent form of recurrent disease in liver transplant programs for the foreseeable future.

Original languageEnglish (US)
Pages (from-to)79-83
Number of pages5
JournalInternational Journal of Medical Sciences
Volume3
Issue number2
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

Keywords

  • Antiviral therapy
  • Liver transplantation
  • Recurrent hepatitis C

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Management of HCV infection and liver transplantation'. Together they form a unique fingerprint.

Cite this