Management of Atypical and Anaplastic Meningiomas

Simon Buttrick, Ashish H. Shah, Ricardo J. Komotar, Michael E. Ivan

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Meningiomas are the most prevalent primary tumor of central nervous system origin and, although most neoplasms are benign, a small proportion exemplifies an aggressive profile characterized by high recurrence rates, pleomorphic histology, and overall resistance to standard treatment. Standard initial therapy for malignant meningiomas includes maximal safe surgical resection followed by focal radiation in certain cases. The role for chemotherapy during recurrence of these aggressive meningiomas is less clear. Prognosis is poor and recurrence of malignant meningiomas is high. This article provides an overview of atypical and anaplastic malignant meningiomas, their treatment, and ongoing research for more effective treatments.

Original languageEnglish (US)
Pages (from-to)239-247
Number of pages9
JournalNeurosurgery clinics of North America
Issue number2
StatePublished - Apr 1 2016


  • Anaplastic meningioma
  • Atypical meningioma
  • Chemotherapy
  • Malignant meningioma
  • Malignant meningioma
  • Radiation therapy
  • Recurrence

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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