Mamu-B*08-positive macaques control simian immunodeficiency virus replication

John T. Loffredo, Jess Maxwell, Ying Qi, Chrystal E. Glidden, Gretta J. Borchardt, Taeko Soma, Alex T. Bean, Dominic R. Beal, Nancy A. Wilson, William M. Rehrauer, Jeffrey D. Lifson, Mary Carrington, David I. Watkins

Research output: Contribution to journalArticlepeer-review

215 Scopus citations

Abstract

Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SrVmac239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.

Original languageEnglish (US)
Pages (from-to)8827-8832
Number of pages6
JournalJournal of virology
Volume81
Issue number16
DOIs
StatePublished - Aug 2007
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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