Mamu-B*08-positive macaques control simian immunodeficiency virus replication

John T. Loffredo, Jess Maxwell, Ying Qi, Chrystal E. Glidden, Gretta J. Borchardt, Taeko Soma, Alex T. Bean, Dominic R. Beal, Nancy A. Wilson, William M. Rehrauer, Jeffrey D. Lifson, Mary Carrington, David Watkins

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SrVmac239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.

Original languageEnglish
Pages (from-to)8827-8832
Number of pages6
JournalJournal of Virology
Volume81
Issue number16
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

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Simian immunodeficiency virus
Simian Immunodeficiency Virus
Macaca
Virus Replication
virus replication
major histocompatibility complex
Major Histocompatibility Complex
Alleles
alleles
Macaca mulatta
Viremia
viremia
Human immunodeficiency virus
HIV
Polymerase Chain Reaction
HIV long-term survivors

ASJC Scopus subject areas

  • Immunology

Cite this

Loffredo, J. T., Maxwell, J., Qi, Y., Glidden, C. E., Borchardt, G. J., Soma, T., ... Watkins, D. (2007). Mamu-B*08-positive macaques control simian immunodeficiency virus replication. Journal of Virology, 81(16), 8827-8832. https://doi.org/10.1128/JVI.00895-07

Mamu-B*08-positive macaques control simian immunodeficiency virus replication. / Loffredo, John T.; Maxwell, Jess; Qi, Ying; Glidden, Chrystal E.; Borchardt, Gretta J.; Soma, Taeko; Bean, Alex T.; Beal, Dominic R.; Wilson, Nancy A.; Rehrauer, William M.; Lifson, Jeffrey D.; Carrington, Mary; Watkins, David.

In: Journal of Virology, Vol. 81, No. 16, 01.08.2007, p. 8827-8832.

Research output: Contribution to journalArticle

Loffredo, JT, Maxwell, J, Qi, Y, Glidden, CE, Borchardt, GJ, Soma, T, Bean, AT, Beal, DR, Wilson, NA, Rehrauer, WM, Lifson, JD, Carrington, M & Watkins, D 2007, 'Mamu-B*08-positive macaques control simian immunodeficiency virus replication', Journal of Virology, vol. 81, no. 16, pp. 8827-8832. https://doi.org/10.1128/JVI.00895-07
Loffredo JT, Maxwell J, Qi Y, Glidden CE, Borchardt GJ, Soma T et al. Mamu-B*08-positive macaques control simian immunodeficiency virus replication. Journal of Virology. 2007 Aug 1;81(16):8827-8832. https://doi.org/10.1128/JVI.00895-07
Loffredo, John T. ; Maxwell, Jess ; Qi, Ying ; Glidden, Chrystal E. ; Borchardt, Gretta J. ; Soma, Taeko ; Bean, Alex T. ; Beal, Dominic R. ; Wilson, Nancy A. ; Rehrauer, William M. ; Lifson, Jeffrey D. ; Carrington, Mary ; Watkins, David. / Mamu-B*08-positive macaques control simian immunodeficiency virus replication. In: Journal of Virology. 2007 ; Vol. 81, No. 16. pp. 8827-8832.
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