Mammalian enzyme induction by hydrocortisone: The possible role of RNA

Leonard D. Garren, R. Rodney Howell, Gordon M. Tomkins

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Administration of hydrocortisone to rats resulted in an increase in the rate of synthesis of nuclear RNA in their livers. This effect was analysed by sedimentation studies of the rapidly labeled components in the liver nucleus and cytoplasm and also by studies of amino acid incorporation stimulated by liver nuclear RNA. It is concluded that the synthesis of various types of RNA, including messenger, are stimulated by the hormone. Simultaneous studies on hormone-induced changes in liver enzymes are compatible with these conclusions.

Original languageEnglish (US)
Pages (from-to)100-108
Number of pages9
JournalJournal of molecular biology
Issue number1
StatePublished - Jan 1 1964
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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