Malnutrition and carbohydrate malabsorption in children with vertically transmitted human immunodeficiency virus 1 infection

Tracie L Miller, E. John Orav, Steven R. Martin, Ellen R. Cooper, Kenneth Mcintosh, Harland S. Winter

Research output: Contribution to journalArticle

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Abstract

The nutritional needs of children with human immunodeficiency virus infection are poorly understood. Twenty-eight children with vertically transmitted human immunodeficiency virus infection were evaluated for carbohydrate malabsorption using lactose hydrogen breath tests and d-xylose absorption studies. Lactose malabsorption was a common finding in human immunodeficiency virus-infected children and occurred in 8 of 20 patients who had no identifiable enteric pathogen. Lactose malabsorption occurred at an earlier age in human immunodeficiency virus-infected children than in an age-matched group of 45 symptomatic control children (P = 0.02). However, lactose malabsorption was not associated with higher rates of diarrhea or growth failure. Abnormalities in d-xylose absorption were not significantly associated with either diarrhea or growth failure. However, 39% of d-xylose studies (9 of 23) showed abnormal results and were significantly associated with enteric infections (P = 0.004). Abnormalities in small-bowel morphology were found in 4 of 9 children with growth failure, 3 of whom had an enteric infection and low d-xylose absorption. Lactose hydrogen breath testing and d-xylose testing showed carbohydrate malabsorption in 61% of children (17 of 28). This study demonstrates that human immunodeficiency virus-infected children are at risk for malabsorptive disorders, which are not always related to clinical symptoms. We speculate that human immunodeficiency virus may be directly involved in the development of lactose malabsorption. Carbohydrate malabsorption in human immunodeficiency virus-infected chil-dren may not be the only factor responsible for growth failure.

Original languageEnglish
Pages (from-to)1296-1302
Number of pages7
JournalGastroenterology
Volume100
Issue number5
StatePublished - Dec 1 1991
Externally publishedYes

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Virus Diseases
Malnutrition
HIV-1
Lactose Intolerance
Carbohydrates
Xylose
HIV
Hydrogen
Diarrhea
Growth
Breath Tests
Lactose
Infection
Intercellular Signaling Peptides and Proteins
Research Design
Age Groups

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Miller, T. L., John Orav, E., Martin, S. R., Cooper, E. R., Mcintosh, K., & Winter, H. S. (1991). Malnutrition and carbohydrate malabsorption in children with vertically transmitted human immunodeficiency virus 1 infection. Gastroenterology, 100(5), 1296-1302.

Malnutrition and carbohydrate malabsorption in children with vertically transmitted human immunodeficiency virus 1 infection. / Miller, Tracie L; John Orav, E.; Martin, Steven R.; Cooper, Ellen R.; Mcintosh, Kenneth; Winter, Harland S.

In: Gastroenterology, Vol. 100, No. 5, 01.12.1991, p. 1296-1302.

Research output: Contribution to journalArticle

Miller, TL, John Orav, E, Martin, SR, Cooper, ER, Mcintosh, K & Winter, HS 1991, 'Malnutrition and carbohydrate malabsorption in children with vertically transmitted human immunodeficiency virus 1 infection', Gastroenterology, vol. 100, no. 5, pp. 1296-1302.
Miller TL, John Orav E, Martin SR, Cooper ER, Mcintosh K, Winter HS. Malnutrition and carbohydrate malabsorption in children with vertically transmitted human immunodeficiency virus 1 infection. Gastroenterology. 1991 Dec 1;100(5):1296-1302.
Miller, Tracie L ; John Orav, E. ; Martin, Steven R. ; Cooper, Ellen R. ; Mcintosh, Kenneth ; Winter, Harland S. / Malnutrition and carbohydrate malabsorption in children with vertically transmitted human immunodeficiency virus 1 infection. In: Gastroenterology. 1991 ; Vol. 100, No. 5. pp. 1296-1302.
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