Malignant tumors of the parotid gland in children: Incidence and outcomes

Bassan J. Allan, Jun Tashiro, Sofia Diaz, Jason Edens, Ramzi T Younis, Seth Thaller

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

BACKGROUND: Population-based analysis of the incidence, demographics, and management outcomes in children with malignant tumors of the parotid gland. METHODS: Surveillance, Epidemiology, and End Results database (1973-2009) was researched for all patients younger than 20 years. RESULTS: Overall, 284 patients were identified. Annual incidence of these tumors was 1.43 cases per million. The highest incidence occurred in girls (0.86/1,000,000), black children (0.849/1,000,000), and adolescents (1.56/1,000,000). Median age at diagnosis was 13.5 years. Most patients were 10 years or older (n = 256, 90%). Most patients presented with local disease (n = 207, 76%). Only 3% had metastasis at time of diagnosis. Most tumors were mucoepidermoid carcinomas (n = 139, 49%) or acinar cell carcinomas (n = 113, 40%). There were no differences in survival between mucoepidermoid and acinar cell carcinomas (96% vs 98% respectively, P = 0.317). Overall mortality was 4.6% over the study period. Overall survival was 96% at 5 years, 95% at 10 years, and 83% at 20 years. Adolescents had significantly higher mortality rates (7.1% vs 1.6% for children <15 years of age, P = 0.23). Multivariate analysis identified the use of adjuvant radiation therapy (hazard ratio, 6.01; 95% confidence interval, 1.15-31.45; P = 0.034) as the only independent predictor of poor outcome. CONCLUSIONS: Malignant parotid gland tumors are most common in adolescents, and this subgroup has worse outcomes. The role of radiotherapy remains controversial.

Original languageEnglish
Pages (from-to)1660-1664
Number of pages5
JournalJournal of Craniofacial Surgery
Volume24
Issue number5
DOIs
StatePublished - Sep 1 2013

Fingerprint

Parotid Gland
Acinar Cell Carcinoma
Incidence
Neoplasms
Radiotherapy
Mucoepidermoid Carcinoma
Survival
Mortality
Epidemiology
Multivariate Analysis
Demography
Databases
Confidence Intervals
Neoplasm Metastasis
Population

Keywords

  • Incidence
  • Malignancy
  • Outcomes
  • Parotid gland
  • Pediatrics

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Malignant tumors of the parotid gland in children : Incidence and outcomes. / Allan, Bassan J.; Tashiro, Jun; Diaz, Sofia; Edens, Jason; Younis, Ramzi T; Thaller, Seth.

In: Journal of Craniofacial Surgery, Vol. 24, No. 5, 01.09.2013, p. 1660-1664.

Research output: Contribution to journalArticle

Allan, Bassan J. ; Tashiro, Jun ; Diaz, Sofia ; Edens, Jason ; Younis, Ramzi T ; Thaller, Seth. / Malignant tumors of the parotid gland in children : Incidence and outcomes. In: Journal of Craniofacial Surgery. 2013 ; Vol. 24, No. 5. pp. 1660-1664.
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AU - Thaller, Seth

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N2 - BACKGROUND: Population-based analysis of the incidence, demographics, and management outcomes in children with malignant tumors of the parotid gland. METHODS: Surveillance, Epidemiology, and End Results database (1973-2009) was researched for all patients younger than 20 years. RESULTS: Overall, 284 patients were identified. Annual incidence of these tumors was 1.43 cases per million. The highest incidence occurred in girls (0.86/1,000,000), black children (0.849/1,000,000), and adolescents (1.56/1,000,000). Median age at diagnosis was 13.5 years. Most patients were 10 years or older (n = 256, 90%). Most patients presented with local disease (n = 207, 76%). Only 3% had metastasis at time of diagnosis. Most tumors were mucoepidermoid carcinomas (n = 139, 49%) or acinar cell carcinomas (n = 113, 40%). There were no differences in survival between mucoepidermoid and acinar cell carcinomas (96% vs 98% respectively, P = 0.317). Overall mortality was 4.6% over the study period. Overall survival was 96% at 5 years, 95% at 10 years, and 83% at 20 years. Adolescents had significantly higher mortality rates (7.1% vs 1.6% for children <15 years of age, P = 0.23). Multivariate analysis identified the use of adjuvant radiation therapy (hazard ratio, 6.01; 95% confidence interval, 1.15-31.45; P = 0.034) as the only independent predictor of poor outcome. CONCLUSIONS: Malignant parotid gland tumors are most common in adolescents, and this subgroup has worse outcomes. The role of radiotherapy remains controversial.

AB - BACKGROUND: Population-based analysis of the incidence, demographics, and management outcomes in children with malignant tumors of the parotid gland. METHODS: Surveillance, Epidemiology, and End Results database (1973-2009) was researched for all patients younger than 20 years. RESULTS: Overall, 284 patients were identified. Annual incidence of these tumors was 1.43 cases per million. The highest incidence occurred in girls (0.86/1,000,000), black children (0.849/1,000,000), and adolescents (1.56/1,000,000). Median age at diagnosis was 13.5 years. Most patients were 10 years or older (n = 256, 90%). Most patients presented with local disease (n = 207, 76%). Only 3% had metastasis at time of diagnosis. Most tumors were mucoepidermoid carcinomas (n = 139, 49%) or acinar cell carcinomas (n = 113, 40%). There were no differences in survival between mucoepidermoid and acinar cell carcinomas (96% vs 98% respectively, P = 0.317). Overall mortality was 4.6% over the study period. Overall survival was 96% at 5 years, 95% at 10 years, and 83% at 20 years. Adolescents had significantly higher mortality rates (7.1% vs 1.6% for children <15 years of age, P = 0.23). Multivariate analysis identified the use of adjuvant radiation therapy (hazard ratio, 6.01; 95% confidence interval, 1.15-31.45; P = 0.034) as the only independent predictor of poor outcome. CONCLUSIONS: Malignant parotid gland tumors are most common in adolescents, and this subgroup has worse outcomes. The role of radiotherapy remains controversial.

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