Malignant rhabdoid tumor of the vulva: Is distinction from epithelioid sarcoma possible? A pathologic and immunohistochemical study

T. Perrone, P. E. Swanson, L. Twiggs, T. M. Ulbright, L. P. Dehner

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Abstract

Epithelioid sarcoma (ES) and malignant rhabdoid tumor (MRT) have herefore been regarded as two separate clinicopathologic entities. However, they have some histologic similarities, and both represent histogenetic and phenotypic engimas. This study reports the pathologic and immunohistochemical findings of four vulvar neoplasms occurring in young women that represented diagnostic dilemmas because of their similarity to both ES and MRT. Only one case had the classic histologic features of ES, whereas, in our opinion, the other three cases fulfilled the histologic criteria of MRT, despite the fact that two of the three cases were reported earlier as examples of ES. Neither electron microscopy nor immunohistochemistry has been found to be helpful in separating ES from MRT, mainly because they share several ultrastuctural and immunophenotypic features. The behavior of these vulvar tumors - ours and the few published examples of ES - is generally aggressive, more in keeping with MRT than classic ES. We believe that some, if not most, putative ES of the vulva are in fact MRT, a neoplasm with an unfavorable prognosis.

Original languageEnglish
Pages (from-to)848-858
Number of pages11
JournalAmerican Journal of Surgical Pathology
Volume13
Issue number10
StatePublished - Jan 1 1989
Externally publishedYes

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Rhabdoid Tumor
Vulva
Sarcoma
Vulvar Neoplasms
Neoplasms
Electron Microscopy
Immunohistochemistry

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Malignant rhabdoid tumor of the vulva : Is distinction from epithelioid sarcoma possible? A pathologic and immunohistochemical study. / Perrone, T.; Swanson, P. E.; Twiggs, L.; Ulbright, T. M.; Dehner, L. P.

In: American Journal of Surgical Pathology, Vol. 13, No. 10, 01.01.1989, p. 848-858.

Research output: Contribution to journalArticle

Perrone, T. ; Swanson, P. E. ; Twiggs, L. ; Ulbright, T. M. ; Dehner, L. P. / Malignant rhabdoid tumor of the vulva : Is distinction from epithelioid sarcoma possible? A pathologic and immunohistochemical study. In: American Journal of Surgical Pathology. 1989 ; Vol. 13, No. 10. pp. 848-858.
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