Malignant mixed mullerian tumor versus high-grade endometrial carcinoma and aggressive variants of endometrial carcinoma: A comparative analysis of survival

E. George, T. J. Lillemoe, L. B. Twiggs, T. Perrone

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

To ascertain whether uterine malignant mixed mullerian tumors are biologically distinct from high-grade endometrial carcinomas (FIGO grade 3), we compared patient survival in 32 and 39 cases, respectively. The Cox proportional hazard model was employed to determine whether tumor type was an independent predictor of survival. The survival of patients with MMMT was also compared to that of patients with serous adenocarcinoma and clear cell carcinoma. The 5-year overall and disease-free survival were significantly lower for malignant mixed mullerian tumors (25% and 11%) than for high-grade endometrial carcinomas (64% and 56%). Using the Cox proportional hazard model, tumor type (MMMT vs. high-grade endometrial carcinoma) was a statistically significant predictor of survival after other important prognostic variables such as pathologic stage, depth of myometrial invasion, and vascular invasion had been taken into account. The increased aggressiveness of MMMT appears most attributable to their tendency to reach a more advanced stage by the time of clinical presentation and to their greater propensity for upper abdominal dissemination. The survival of patients with MMMT was also lower than that of patients with the special histologic variants of endometrial carcinoma, serous adenocarcinoma and clear cell carcinoma, which are recognized for their unusually aggressive clinical behavior. These results indicate that uterine malignant mixed mullerian tumors are clinically more aggressive than high-grade endometrial carcinomas and should continue to be recognized as a distinct entity.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalInternational Journal of Gynecological Pathology
Volume14
Issue number1
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Malignant Mixed Tumor
Endometrial Neoplasms
Survival Analysis
Clear Cell Adenocarcinoma
Survival
Proportional Hazards Models
Carcinoma
Disease-Free Survival
Blood Vessels
Neoplasms

Keywords

  • Carcinosarcoma
  • Clear cell carcinoma
  • Endometrial carcinoma
  • Endometrial neoplasms
  • Malignant mixed mullerian tumors
  • Serous carcinoma
  • Uterine neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pathology and Forensic Medicine

Cite this

Malignant mixed mullerian tumor versus high-grade endometrial carcinoma and aggressive variants of endometrial carcinoma : A comparative analysis of survival. / George, E.; Lillemoe, T. J.; Twiggs, L. B.; Perrone, T.

In: International Journal of Gynecological Pathology, Vol. 14, No. 1, 01.01.1995, p. 39-44.

Research output: Contribution to journalArticle

@article{47fb162eda464023a5d367a3e2025259,
title = "Malignant mixed mullerian tumor versus high-grade endometrial carcinoma and aggressive variants of endometrial carcinoma: A comparative analysis of survival",
abstract = "To ascertain whether uterine malignant mixed mullerian tumors are biologically distinct from high-grade endometrial carcinomas (FIGO grade 3), we compared patient survival in 32 and 39 cases, respectively. The Cox proportional hazard model was employed to determine whether tumor type was an independent predictor of survival. The survival of patients with MMMT was also compared to that of patients with serous adenocarcinoma and clear cell carcinoma. The 5-year overall and disease-free survival were significantly lower for malignant mixed mullerian tumors (25{\%} and 11{\%}) than for high-grade endometrial carcinomas (64{\%} and 56{\%}). Using the Cox proportional hazard model, tumor type (MMMT vs. high-grade endometrial carcinoma) was a statistically significant predictor of survival after other important prognostic variables such as pathologic stage, depth of myometrial invasion, and vascular invasion had been taken into account. The increased aggressiveness of MMMT appears most attributable to their tendency to reach a more advanced stage by the time of clinical presentation and to their greater propensity for upper abdominal dissemination. The survival of patients with MMMT was also lower than that of patients with the special histologic variants of endometrial carcinoma, serous adenocarcinoma and clear cell carcinoma, which are recognized for their unusually aggressive clinical behavior. These results indicate that uterine malignant mixed mullerian tumors are clinically more aggressive than high-grade endometrial carcinomas and should continue to be recognized as a distinct entity.",
keywords = "Carcinosarcoma, Clear cell carcinoma, Endometrial carcinoma, Endometrial neoplasms, Malignant mixed mullerian tumors, Serous carcinoma, Uterine neoplasms",
author = "E. George and Lillemoe, {T. J.} and Twiggs, {L. B.} and T. Perrone",
year = "1995",
month = "1",
day = "1",
language = "English",
volume = "14",
pages = "39--44",
journal = "International Journal of Gynecological Pathology",
issn = "0277-1691",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Malignant mixed mullerian tumor versus high-grade endometrial carcinoma and aggressive variants of endometrial carcinoma

T2 - A comparative analysis of survival

AU - George, E.

AU - Lillemoe, T. J.

AU - Twiggs, L. B.

AU - Perrone, T.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - To ascertain whether uterine malignant mixed mullerian tumors are biologically distinct from high-grade endometrial carcinomas (FIGO grade 3), we compared patient survival in 32 and 39 cases, respectively. The Cox proportional hazard model was employed to determine whether tumor type was an independent predictor of survival. The survival of patients with MMMT was also compared to that of patients with serous adenocarcinoma and clear cell carcinoma. The 5-year overall and disease-free survival were significantly lower for malignant mixed mullerian tumors (25% and 11%) than for high-grade endometrial carcinomas (64% and 56%). Using the Cox proportional hazard model, tumor type (MMMT vs. high-grade endometrial carcinoma) was a statistically significant predictor of survival after other important prognostic variables such as pathologic stage, depth of myometrial invasion, and vascular invasion had been taken into account. The increased aggressiveness of MMMT appears most attributable to their tendency to reach a more advanced stage by the time of clinical presentation and to their greater propensity for upper abdominal dissemination. The survival of patients with MMMT was also lower than that of patients with the special histologic variants of endometrial carcinoma, serous adenocarcinoma and clear cell carcinoma, which are recognized for their unusually aggressive clinical behavior. These results indicate that uterine malignant mixed mullerian tumors are clinically more aggressive than high-grade endometrial carcinomas and should continue to be recognized as a distinct entity.

AB - To ascertain whether uterine malignant mixed mullerian tumors are biologically distinct from high-grade endometrial carcinomas (FIGO grade 3), we compared patient survival in 32 and 39 cases, respectively. The Cox proportional hazard model was employed to determine whether tumor type was an independent predictor of survival. The survival of patients with MMMT was also compared to that of patients with serous adenocarcinoma and clear cell carcinoma. The 5-year overall and disease-free survival were significantly lower for malignant mixed mullerian tumors (25% and 11%) than for high-grade endometrial carcinomas (64% and 56%). Using the Cox proportional hazard model, tumor type (MMMT vs. high-grade endometrial carcinoma) was a statistically significant predictor of survival after other important prognostic variables such as pathologic stage, depth of myometrial invasion, and vascular invasion had been taken into account. The increased aggressiveness of MMMT appears most attributable to their tendency to reach a more advanced stage by the time of clinical presentation and to their greater propensity for upper abdominal dissemination. The survival of patients with MMMT was also lower than that of patients with the special histologic variants of endometrial carcinoma, serous adenocarcinoma and clear cell carcinoma, which are recognized for their unusually aggressive clinical behavior. These results indicate that uterine malignant mixed mullerian tumors are clinically more aggressive than high-grade endometrial carcinomas and should continue to be recognized as a distinct entity.

KW - Carcinosarcoma

KW - Clear cell carcinoma

KW - Endometrial carcinoma

KW - Endometrial neoplasms

KW - Malignant mixed mullerian tumors

KW - Serous carcinoma

KW - Uterine neoplasms

UR - http://www.scopus.com/inward/record.url?scp=0028979636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028979636&partnerID=8YFLogxK

M3 - Article

C2 - 7883424

AN - SCOPUS:0028979636

VL - 14

SP - 39

EP - 44

JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

SN - 0277-1691

IS - 1

ER -