Malignant melanoma with paradoxical maturation

Steven M. Ruhoy, Victor G. Prieto, Susan L. Eliason, James M Grichnik, James L. Burchette, Christopher R. Shea

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Typically, melanocytic nevi 'mature' (i.e., exhibit a morphologic shift to smaller or spindle cells with progressive depth in the dermis). In contrast, most malignant melanomas (conventional MMs) lack maturation, and are composed of large pleomorphic cells throughout. The authors describe a series of melanomas with paradoxical maturation mimicking the pattern of nevi. Seventeen primary invasive melanomas with paradoxical maturation (IMPs), two epidermotropic metastatic melanomas with maturation (EMMMs), 13 compound nevi (CN), and 14 conventional MMs without apparent maturation were analyzed by histologic, cytomorphometric, and immunohistochemical techniques. With increasing dermal depth, both CN and IMPs had smaller nuclear and cellular areas, and decreased expression of Ki-67, glycoprotein (gp) 100 (with HMB-45), and tyrosinase. IMPs had significant differences from conventional MMs; namely, smaller nuclear and cytoplasmic areas (deep), and decreased expression of Ki-67 (superficial and deep), gp100 (deep), and tyrosinase (deep). IMPs also had notable differences from CN: namely, larger nuclear and cellular areas, more confluence, more mitotic figures, increased Ki-67 and gp100 expression in both the superficial and deep portions, and more melanin (deep). The two EMMMs exhibited histologic and immunohistochemical features similar to the primary IMPs. IMP, because of its mimicry of nevus, can present a diagnostic hazard. The authors propose histologic, morphometric, and immunohistochemical criteria that facilitate recognition and accurate diagnosis of this unusual variant of melanoma.

Original languageEnglish
Pages (from-to)1600-1614
Number of pages15
JournalAmerican Journal of Surgical Pathology
Volume24
Issue number12
DOIs
StatePublished - Dec 14 2000
Externally publishedYes

Fingerprint

Melanoma
Nevus
Monophenol Monooxygenase
Nevi and Melanomas
Pigmented Nevus
Melanins
Dermis
Glycoproteins
Skin

Keywords

  • Image analysis
  • Immunohistochemistry
  • Maturation
  • Melanoma
  • Morphometry
  • Nevus

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Ruhoy, S. M., Prieto, V. G., Eliason, S. L., Grichnik, J. M., Burchette, J. L., & Shea, C. R. (2000). Malignant melanoma with paradoxical maturation. American Journal of Surgical Pathology, 24(12), 1600-1614. https://doi.org/10.1097/00000478-200012000-00003

Malignant melanoma with paradoxical maturation. / Ruhoy, Steven M.; Prieto, Victor G.; Eliason, Susan L.; Grichnik, James M; Burchette, James L.; Shea, Christopher R.

In: American Journal of Surgical Pathology, Vol. 24, No. 12, 14.12.2000, p. 1600-1614.

Research output: Contribution to journalArticle

Ruhoy, SM, Prieto, VG, Eliason, SL, Grichnik, JM, Burchette, JL & Shea, CR 2000, 'Malignant melanoma with paradoxical maturation', American Journal of Surgical Pathology, vol. 24, no. 12, pp. 1600-1614. https://doi.org/10.1097/00000478-200012000-00003
Ruhoy SM, Prieto VG, Eliason SL, Grichnik JM, Burchette JL, Shea CR. Malignant melanoma with paradoxical maturation. American Journal of Surgical Pathology. 2000 Dec 14;24(12):1600-1614. https://doi.org/10.1097/00000478-200012000-00003
Ruhoy, Steven M. ; Prieto, Victor G. ; Eliason, Susan L. ; Grichnik, James M ; Burchette, James L. ; Shea, Christopher R. / Malignant melanoma with paradoxical maturation. In: American Journal of Surgical Pathology. 2000 ; Vol. 24, No. 12. pp. 1600-1614.
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