Primary malignant lymphomas represent approximately 0.5 % of all primary neoplasms of the lung. By contrast, secondary involvement of the lung in patients with systemic lymphoma is common. Most of the primary malignant lymphomas are non-Hodgkin's lymphomas of B-cell lineage and, overall, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is the most common type. The second most frequent lymphoma of the lung is diffuse large B-cell lymphoma (DLBCL), some of them representing large cell transformation of a previous MALT lymphoma. Hodgkin's lymphoma rarely occurs in extranodal sites. Other malignant lymphomas that involve lung and pleura are also discussed including distinct entities such as lymphomatoid granulomatosis, primary effusion lymphomas (PEL), and DLBCL associated with chronic inflammation, also known as pyothorax-associated lymphoma (PAL).
ASJC Scopus subject areas