Malignant fibrous histiocytoma (giant cell type) of the pancreas. A distinctive variant of osteoclast-type giant cell tumor of the pancreas

S. Suster, M. Phillips, M. J. Robinson

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Malignant giant cell tumors of the pancreas are rare neoplasms which have been generally thought to represent epithelial malignancies of either acinar or ductal epithelium. The authors have studied a tumor of the pancreas that was characterized histologically by a proliferation of benign-appearing osteoclasttype giant cells in association with atypical, often bizarre mononuclear cells. Immunohistochemical studies demonstrated negative staining of the tumor cells with epithelial markers, including low-molecular weight keratins, carcinoembryonic antigen and epithelial membrane antigen, and positive staining with vimentin antibodies, supporting a fibroblastic line of differentiation. Electron microscopic examination also showed absence of ultrastructural features of epithelial differentiation such as microvilli, intercellular junctions, or desmosomes. The authors believe the current case represents a true sarcoma of the pancreas, currently from the epithelial type of osteoclastic giant cell tumor of the pancreas

Original languageEnglish
Pages (from-to)2303-2308
Number of pages6
JournalCancer
Volume64
Issue number11
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Giant Cell Tumors
Malignant Fibrous Histiocytoma
Osteoclasts
Giant Cells
Pancreas
Negative Staining
Mucin-1
Neoplasms
Desmosomes
Intercellular Junctions
Carcinoembryonic Antigen
Vimentin
Microvilli
Keratins
Pancreatic Neoplasms
Sarcoma
Epithelium
Molecular Weight
Epithelial Cells
Electrons

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Malignant fibrous histiocytoma (giant cell type) of the pancreas. A distinctive variant of osteoclast-type giant cell tumor of the pancreas. / Suster, S.; Phillips, M.; Robinson, M. J.

In: Cancer, Vol. 64, No. 11, 01.01.1989, p. 2303-2308.

Research output: Contribution to journalArticle

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