TY - JOUR
T1 - Malignant fibrous histiocytoma (giant cell type) of the pancreas. A distinctive variant of osteoclast‐type giant cell tumor of the pancreas
AU - Suster, Saul
AU - Phillips, Mark
AU - Robinson, Morton J.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1989/12/1
Y1 - 1989/12/1
N2 - Malignant giant cell tumors of the pancreas are rare neoplasms which have been generally thought to represent epithelial malignancies of either acinar or ductal epithelium. The authors have studied a tumor of the pancreas that was characterized histologically by a proliferation of benign-appearing osteoclasttype giant cells in association with atypical, often bizarre mononuclear cells. Immunohistochemical studies demonstrated negative staining of the tumor cells with epithelial markers, including low-molecular weight keratins, carcinoembryonic antigen and epithelial membrane antigen, and positive staining with vimentin antibodies, supporting a fibroblastic line of differentiation. Electron microscopic examination also showed absence of ultrastructural features of epithelial differentiation such as microvilli, intercellular junctions, or desmosomes. The authors believe the current case represents a true sarcoma of the pancreas, currently from the epithelial type of osteoclastic giant cell tumor of the pancreas
AB - Malignant giant cell tumors of the pancreas are rare neoplasms which have been generally thought to represent epithelial malignancies of either acinar or ductal epithelium. The authors have studied a tumor of the pancreas that was characterized histologically by a proliferation of benign-appearing osteoclasttype giant cells in association with atypical, often bizarre mononuclear cells. Immunohistochemical studies demonstrated negative staining of the tumor cells with epithelial markers, including low-molecular weight keratins, carcinoembryonic antigen and epithelial membrane antigen, and positive staining with vimentin antibodies, supporting a fibroblastic line of differentiation. Electron microscopic examination also showed absence of ultrastructural features of epithelial differentiation such as microvilli, intercellular junctions, or desmosomes. The authors believe the current case represents a true sarcoma of the pancreas, currently from the epithelial type of osteoclastic giant cell tumor of the pancreas
UR - http://www.scopus.com/inward/record.url?scp=0024470536&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024470536&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19891201)64:11<2303::AID-CNCR2820641120>3.0.CO;2-S
DO - 10.1002/1097-0142(19891201)64:11<2303::AID-CNCR2820641120>3.0.CO;2-S
M3 - Article
C2 - 2553244
AN - SCOPUS:0024470536
VL - 64
SP - 2303
EP - 2308
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 11
ER -