Malignant angioendotheliomatosis-A true lymphoma: A case of intravascular malignant lymphomatosis studied by southern blot hybridization analysis

Christian L. Otrakji, Walter Voigt, Alex Amador, Mehrdad Nadji, Jocelyn B. Gregorios

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Malignant angioendotheliomatosis is a rare, systemic, usually fatal disease characterized by a massive proliferation of large, bizarre-looking mononuclear cells within small and medium-sized blood vessels. The histogenesis of the neoplastic cells has been the subject of long-standing controversy since the disease's initial description. Early investigators concluded that the entity represented a neoplasm of endothelial cells, but recently others have suggested that it is of lymphoid origin. We studied a case of malignant angioen-dotheliomatosis by Southern blot hybridization analysis which showed clonal rearrangements of the immunoglobulin heavy-chain gene strongly suggesting a B-lymphocyte origin. Our results provide additional evidence that malignant angioendotheliomatosis is an intravascular malignant lymphomatosis.

Original languageEnglish (US)
Pages (from-to)475-478
Number of pages4
JournalHuman pathology
Volume19
Issue number4
DOIs
StatePublished - Apr 1988
Externally publishedYes

Keywords

  • angiotropic large cell lymphoma
  • immunoglobulingene rearrangements
  • intravascular malignant lymphomatosis
  • malignant angioendotheliomatosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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