Malarial parasites and antioxidant nutrients

O. A. Levander, Arba L Ager

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Susceptibility to oxidative stress is a well-established feature of the malarial parasite. Pharmacologists have taken advantage of this property to design highly effective pro-oxidant antimalarial drugs. Less well appreciated is the fact that nutritional manipulation of host oxidative stress status by dietary means can have a profound effect on the growth of the parasite. In particular, rapid induction of vitamin E deficiency in mice by feeding highly unsaturated fatty acids (fish oil) strongly suppresses plasmodial growth. Likewise, the status of other antioxidant nutrients (e.g., riboflavin or vitamin C) may also influence the course of malarial infection under certain conditions. A combined nutritional pharmacology approach may offer some promise in controlling malaria.

Original languageEnglish (US)
JournalParasitology
Volume107
Issue numberSUPPL.
StatePublished - 1993

Fingerprint

Parasites
Oxidative Stress
oxidative stress
Antioxidants
Vitamin E Deficiency
antioxidants
vitamin E deficiency
parasites
Food
highly unsaturated fatty acids
antimalarials
Riboflavin
Fish Oils
Antimalarials
nutrients
pharmacology
riboflavin
Growth
Unsaturated Fatty Acids
fish oils

Keywords

  • antioxidant
  • ascorbic acid
  • fish oil
  • lipid peroxidation
  • malaria
  • oxidative stress
  • Plasmodium
  • pro-oxidant
  • riboflavin
  • selenium
  • tocopherol
  • vitamin C
  • vitamin E

ASJC Scopus subject areas

  • Immunology
  • Parasitology

Cite this

Levander, O. A., & Ager, A. L. (1993). Malarial parasites and antioxidant nutrients. Parasitology, 107(SUPPL.).

Malarial parasites and antioxidant nutrients. / Levander, O. A.; Ager, Arba L.

In: Parasitology, Vol. 107, No. SUPPL., 1993.

Research output: Contribution to journalArticle

Levander, OA & Ager, AL 1993, 'Malarial parasites and antioxidant nutrients', Parasitology, vol. 107, no. SUPPL..
Levander OA, Ager AL. Malarial parasites and antioxidant nutrients. Parasitology. 1993;107(SUPPL.).
Levander, O. A. ; Ager, Arba L. / Malarial parasites and antioxidant nutrients. In: Parasitology. 1993 ; Vol. 107, No. SUPPL.
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