Abstract
Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are important for fidelity in intracellular signaling and for mediating crosstalk between the different signaling pathways. These complexes integrate upstream signals and control downstream effectors. In the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to cAMP, calcium, hypoxia, and mitogenactivated protein kinase signaling. The main function of mAKAPβ signalosomes is to modulate stress-related gene expression regulated by the transcription factors NFATc, MEF2, and HIF-1α and type II histone deacetylases that control pathological cardiac hypertrophy
| Original language | English (US) |
|---|---|
| Pages (from-to) | 218-225 |
| Number of pages | 8 |
| Journal | Journal of Cardiovascular Pharmacology |
| Volume | 65 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2015 |
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Keywords
- heart
- mAKAP
- nuclear envelope
- remodeling
- signalosome
ASJC Scopus subject areas
- Pharmacology
- Cardiology and Cardiovascular Medicine
Cite this
MAKAP - A master scaffold for cardiac remodeling. / Passariello, Catherine L.; Li, Jinliang; Dodge-Kafka, Kimberly; Kapiloff, Michael S.
In: Journal of Cardiovascular Pharmacology, Vol. 65, No. 3, 2015, p. 218-225.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MAKAP - A master scaffold for cardiac remodeling
AU - Passariello, Catherine L.
AU - Li, Jinliang
AU - Dodge-Kafka, Kimberly
AU - Kapiloff, Michael S
PY - 2015
Y1 - 2015
N2 - Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are important for fidelity in intracellular signaling and for mediating crosstalk between the different signaling pathways. These complexes integrate upstream signals and control downstream effectors. In the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to cAMP, calcium, hypoxia, and mitogenactivated protein kinase signaling. The main function of mAKAPβ signalosomes is to modulate stress-related gene expression regulated by the transcription factors NFATc, MEF2, and HIF-1α and type II histone deacetylases that control pathological cardiac hypertrophy
AB - Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are important for fidelity in intracellular signaling and for mediating crosstalk between the different signaling pathways. These complexes integrate upstream signals and control downstream effectors. In the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to cAMP, calcium, hypoxia, and mitogenactivated protein kinase signaling. The main function of mAKAPβ signalosomes is to modulate stress-related gene expression regulated by the transcription factors NFATc, MEF2, and HIF-1α and type II histone deacetylases that control pathological cardiac hypertrophy
KW - heart
KW - mAKAP
KW - nuclear envelope
KW - remodeling
KW - signalosome
UR - http://www.scopus.com/inward/record.url?scp=84925535523&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925535523&partnerID=8YFLogxK
U2 - 10.1097/FJC.0000000000000206
DO - 10.1097/FJC.0000000000000206
M3 - Article
C2 - 25551320
AN - SCOPUS:84925535523
VL - 65
SP - 218
EP - 225
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - 3
ER -