MAKAP - A master scaffold for cardiac remodeling

Catherine L. Passariello, Jinliang Li, Kimberly Dodge-Kafka, Michael S. Kapiloff

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are important for fidelity in intracellular signaling and for mediating crosstalk between the different signaling pathways. These complexes integrate upstream signals and control downstream effectors. In the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to cAMP, calcium, hypoxia, and mitogenactivated protein kinase signaling. The main function of mAKAPβ signalosomes is to modulate stress-related gene expression regulated by the transcription factors NFATc, MEF2, and HIF-1α and type II histone deacetylases that control pathological cardiac hypertrophy

Original languageEnglish (US)
Pages (from-to)218-225
Number of pages8
JournalJournal of Cardiovascular Pharmacology
Volume65
Issue number3
DOIs
StatePublished - Mar 2015

Keywords

  • heart
  • mAKAP
  • nuclear envelope
  • remodeling
  • signalosome

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Passariello, C. L., Li, J., Dodge-Kafka, K., & Kapiloff, M. S. (2015). MAKAP - A master scaffold for cardiac remodeling. Journal of Cardiovascular Pharmacology, 65(3), 218-225. https://doi.org/10.1097/FJC.0000000000000206