TY - JOUR
T1 - MAKAP - A master scaffold for cardiac remodeling
AU - Passariello, Catherine L.
AU - Li, Jinliang
AU - Dodge-Kafka, Kimberly
AU - Kapiloff, Michael S.
N1 - Publisher Copyright:
© 2014 Wolters Kluwer Health, Inc. All rights reserved..
PY - 2015/3
Y1 - 2015/3
N2 - Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are important for fidelity in intracellular signaling and for mediating crosstalk between the different signaling pathways. These complexes integrate upstream signals and control downstream effectors. In the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to cAMP, calcium, hypoxia, and mitogenactivated protein kinase signaling. The main function of mAKAPβ signalosomes is to modulate stress-related gene expression regulated by the transcription factors NFATc, MEF2, and HIF-1α and type II histone deacetylases that control pathological cardiac hypertrophy
AB - Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are important for fidelity in intracellular signaling and for mediating crosstalk between the different signaling pathways. These complexes integrate upstream signals and control downstream effectors. In the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to cAMP, calcium, hypoxia, and mitogenactivated protein kinase signaling. The main function of mAKAPβ signalosomes is to modulate stress-related gene expression regulated by the transcription factors NFATc, MEF2, and HIF-1α and type II histone deacetylases that control pathological cardiac hypertrophy
KW - heart
KW - mAKAP
KW - nuclear envelope
KW - remodeling
KW - signalosome
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U2 - 10.1097/FJC.0000000000000206
DO - 10.1097/FJC.0000000000000206
M3 - Review article
C2 - 25551320
AN - SCOPUS:84925535523
VL - 65
SP - 218
EP - 225
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - 3
ER -