Major histocompatibility complex class I genes in primates: Co-evolution with pathogens

Thorsten U. Vogel, David T. Evans, Julie A. Urvater, David H. O'Connor, Austin L. Hughes, David I. Watkins

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

The major histocompatibility complex (MHC) is the most polymorphic genetic system known, playing a central role in the cellular immune response to pathogens. The relationship between the MHC of humans and non-human primates has increased our understanding of MHC evolution and how polymorphism of this gene family may have been generated. We will review MHC class I evolution in great apes and Old World and New World primates and discuss new data from the simian immunodeficiency virus/rhesus monkey animal model that demonstrate the role of MHC class I alleles in selecting for new populations of viruses. This suggests that certain pathogens co-evolve with the MHC class I molecules they encounter in a population.

Original languageEnglish (US)
Pages (from-to)327-337
Number of pages11
JournalImmunological reviews
Volume167
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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