Major histocompatibility complex class I genes in primates: Co-evolution with pathogens

Thorsten U. Vogel, David T. Evans, Julie A. Urvater, David H. O'Connor, Austin L. Hughes, David Watkins

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The major histocompatibility complex (MHC) is the most polymorphic genetic system known, playing a central role in the cellular immune response to pathogens. The relationship between the MHC of humans and non-human primates has increased our understanding of MHC evolution and how polymorphism of this gene family may have been generated. We will review MHC class I evolution in great apes and Old World and New World primates and discuss new data from the simian immunodeficiency virus/rhesus monkey animal model that demonstrate the role of MHC class I alleles in selecting for new populations of viruses. This suggests that certain pathogens co-evolve with the MHC class I molecules they encounter in a population.

Original languageEnglish
Pages (from-to)327-337
Number of pages11
JournalImmunological Reviews
Volume167
StatePublished - Apr 26 1999
Externally publishedYes

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MHC Class I Genes
Major Histocompatibility Complex
Primates
Simian Immunodeficiency Virus
Hominidae
Macaca mulatta
Cellular Immunity
Population
Animal Models
Alleles
Viruses
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Vogel, T. U., Evans, D. T., Urvater, J. A., O'Connor, D. H., Hughes, A. L., & Watkins, D. (1999). Major histocompatibility complex class I genes in primates: Co-evolution with pathogens. Immunological Reviews, 167, 327-337.

Major histocompatibility complex class I genes in primates : Co-evolution with pathogens. / Vogel, Thorsten U.; Evans, David T.; Urvater, Julie A.; O'Connor, David H.; Hughes, Austin L.; Watkins, David.

In: Immunological Reviews, Vol. 167, 26.04.1999, p. 327-337.

Research output: Contribution to journalArticle

Vogel, TU, Evans, DT, Urvater, JA, O'Connor, DH, Hughes, AL & Watkins, D 1999, 'Major histocompatibility complex class I genes in primates: Co-evolution with pathogens', Immunological Reviews, vol. 167, pp. 327-337.
Vogel TU, Evans DT, Urvater JA, O'Connor DH, Hughes AL, Watkins D. Major histocompatibility complex class I genes in primates: Co-evolution with pathogens. Immunological Reviews. 1999 Apr 26;167:327-337.
Vogel, Thorsten U. ; Evans, David T. ; Urvater, Julie A. ; O'Connor, David H. ; Hughes, Austin L. ; Watkins, David. / Major histocompatibility complex class I genes in primates : Co-evolution with pathogens. In: Immunological Reviews. 1999 ; Vol. 167. pp. 327-337.
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