Major histocompatibility complex class I genes in primates: Co-evolution with pathogens

Thorsten U. Vogel, David T. Evans, Julie A. Urvater, David H. O'Connor, Austin L. Hughes, David Watkins

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

The major histocompatibility complex (MHC) is the most polymorphic genetic system known, playing a central role in the cellular immune response to pathogens. The relationship between the MHC of humans and non-human primates has increased our understanding of MHC evolution and how polymorphism of this gene family may have been generated. We will review MHC class I evolution in great apes and Old World and New World primates and discuss new data from the simian immunodeficiency virus/rhesus monkey animal model that demonstrate the role of MHC class I alleles in selecting for new populations of viruses. This suggests that certain pathogens co-evolve with the MHC class I molecules they encounter in a population.

Original languageEnglish
Pages (from-to)327-337
Number of pages11
JournalImmunological Reviews
Volume167
StatePublished - Apr 26 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

Cite this

Vogel, T. U., Evans, D. T., Urvater, J. A., O'Connor, D. H., Hughes, A. L., & Watkins, D. (1999). Major histocompatibility complex class I genes in primates: Co-evolution with pathogens. Immunological Reviews, 167, 327-337.