TY - JOUR
T1 - Maintenance theophylline therapy in children
T2 - Effect on urinary calcium, phosphate and cyclic AMP excretion
AU - Colin, A. A.
AU - Hochberg, Z.
AU - Kraiem, Z.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - Eleven children, five females and six males, aged 3 to 15 years, were included in the study. They had suffered from chronic asthma for periods of 1 to 8 years and had been on long-term therapy with theophylline for 3 to 12 months. Theophylline was taken orally as Theo-Dur (Key Pharmaceuticals) in two daily doses of 7 to 14 mg/kg per dose. Serum levels were monitored bimonthly and were maintained at 10 to 20 μg/ml. Each child served as his own control. Pretreatment values were taken for serum calcium, serum phosphorus, serum creatinine, serum cyclic AMP, urinary calcium and phosphate, urinary creatinine and urinary cyclic AMP. During the study period, the patients were given a constant calcium diet of 800 mg/m2 per day for 7 days. On the seventh day of the diet, urine was collected for 24 hours, and blood was drawn at 9 o'clock on the next morning. Plasma and urinary cyclic AMP were determined by a competitive protein-binding assay, (4) and nephrogenous cyclic AMP was calculated according to Broadus et al. (5). The intra- and interassay coefficients of variation were 4.6% and 7.1%, respectively.
AB - Eleven children, five females and six males, aged 3 to 15 years, were included in the study. They had suffered from chronic asthma for periods of 1 to 8 years and had been on long-term therapy with theophylline for 3 to 12 months. Theophylline was taken orally as Theo-Dur (Key Pharmaceuticals) in two daily doses of 7 to 14 mg/kg per dose. Serum levels were monitored bimonthly and were maintained at 10 to 20 μg/ml. Each child served as his own control. Pretreatment values were taken for serum calcium, serum phosphorus, serum creatinine, serum cyclic AMP, urinary calcium and phosphate, urinary creatinine and urinary cyclic AMP. During the study period, the patients were given a constant calcium diet of 800 mg/m2 per day for 7 days. On the seventh day of the diet, urine was collected for 24 hours, and blood was drawn at 9 o'clock on the next morning. Plasma and urinary cyclic AMP were determined by a competitive protein-binding assay, (4) and nephrogenous cyclic AMP was calculated according to Broadus et al. (5). The intra- and interassay coefficients of variation were 4.6% and 7.1%, respectively.
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U2 - 10.1111/j.1651-2227.1987.tb10481.x
DO - 10.1111/j.1651-2227.1987.tb10481.x
M3 - Article
C2 - 3035863
AN - SCOPUS:0023090859
VL - 76
SP - 367
EP - 368
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
SN - 0803-5253
IS - 2
ER -