Maintenance of genome stability by Fanconi anemia proteins

Anna Palovcak, Wenjun Liu, Fenghua Yuan, Yanbin Zhang

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Persistent dysregulation of the DNA damage response and repair in cells causes genomic instability. The resulting genetic changes permit alterations in growth and proliferation observed in virtually all cancers. However, an unstable genome can serve as a double-edged sword by providing survival advantages in the ability to evade checkpoint signaling, but also creating vulnerabilities through dependency on alternative genomic maintenance factors. The Fanconi anemia pathway comprises an intricate network of DNA damage signaling and repair that are critical for protection against genomic instability. The importance of this pathway is underlined by the severity of the cancer predisposing syndrome Fanconi anemia which can be caused by biallelic mutations in any one of the 21 genes known thus far. This review delineates the roles of the Fanconi anemia pathway and the molecular actions of Fanconi anemia proteins in confronting replicative, oxidative, and mitotic stress.

Original languageEnglish (US)
Article number8
JournalCell and Bioscience
Volume7
Issue number1
DOIs
StatePublished - Feb 22 2017

Fingerprint

Fanconi Anemia Complementation Group Proteins
Fanconi Anemia
Genomic Instability
Repair
Genes
Maintenance
DNA Repair
DNA Damage
DNA
Neoplasms
Oxidative Stress
Genome
Mutation
Growth

Keywords

  • DNA damage response
  • DNA repair
  • FANCA
  • Fanconi anemia
  • Genome instability

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Maintenance of genome stability by Fanconi anemia proteins. / Palovcak, Anna; Liu, Wenjun; Yuan, Fenghua; Zhang, Yanbin.

In: Cell and Bioscience, Vol. 7, No. 1, 8, 22.02.2017.

Research output: Contribution to journalReview article

Palovcak, Anna ; Liu, Wenjun ; Yuan, Fenghua ; Zhang, Yanbin. / Maintenance of genome stability by Fanconi anemia proteins. In: Cell and Bioscience. 2017 ; Vol. 7, No. 1.
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