Magnetoelectric 'spin' on stimulating the brain

Rakesh Guduru; Ping Liang; J. Hong; Alexandra Rodzinski; Ali Hadjikhani; Jeffrey Horstmyer; Ernest Levister; Sakhrat Khizroev

doi:10.2217/nnm.15.52

Magnetoelectric 'spin' on stimulating the brain

Rakesh Guduru, Ping Liang, J. Hong, Alexandra Rodzinski, Ali Hadjikhani, Jeffrey Horstmyer, Ernest Levister, Sakhrat Khizroev

Electrical & Computer Engineering

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Aim: The in vivo study on imprinting control region mice aims to show that magnetoelectric nanoparticles may directly couple the intrinsic neural activity-induced electric fields with external magnetic fields. Methods: Approximately 10 μg of CoFe₂O₄-BaTiO₃ 30-nm nanoparticles have been intravenously administrated through a tail vein and forced to cross the blood-brain barrier via a d.c. field gradient of 3000 Oe/cm. A surgically attached two-channel electroencephalography headmount has directly measured the modulation of intrinsic electric waveforms by an external a.c. 100-Oe magnetic field in a frequency range of 0-20 Hz. Results: The modulated signal has reached the strength comparable to that due the regular neural activity. Conclusion: The study opens a pathway to use multifunctional nanoparticles to control intrinsic fields deep in the brain.

Original language	English (US)
Pages (from-to)	2051-2061
Number of pages	11
Journal	Nanomedicine
Volume	10
Issue number	13
DOIs	https://doi.org/10.2217/nnm.15.52
State	Published - Jul 1 2015

Keywords

magnetoelectric nanoparticles
nanoengineering the brain
noninvasive brain stimulation

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Materials Science(all)

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10.2217/nnm.15.52

Cite this

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title = "Magnetoelectric 'spin' on stimulating the brain",

abstract = "Aim: The in vivo study on imprinting control region mice aims to show that magnetoelectric nanoparticles may directly couple the intrinsic neural activity-induced electric fields with external magnetic fields. Methods: Approximately 10 μg of CoFe2O4-BaTiO3 30-nm nanoparticles have been intravenously administrated through a tail vein and forced to cross the blood-brain barrier via a d.c. field gradient of 3000 Oe/cm. A surgically attached two-channel electroencephalography headmount has directly measured the modulation of intrinsic electric waveforms by an external a.c. 100-Oe magnetic field in a frequency range of 0-20 Hz. Results: The modulated signal has reached the strength comparable to that due the regular neural activity. Conclusion: The study opens a pathway to use multifunctional nanoparticles to control intrinsic fields deep in the brain.",

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AU - Liang, Ping

AU - Hong, J.

AU - Rodzinski, Alexandra

AU - Hadjikhani, Ali

AU - Horstmyer, Jeffrey

AU - Levister, Ernest

AU - Khizroev, Sakhrat

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Aim: The in vivo study on imprinting control region mice aims to show that magnetoelectric nanoparticles may directly couple the intrinsic neural activity-induced electric fields with external magnetic fields. Methods: Approximately 10 μg of CoFe2O4-BaTiO3 30-nm nanoparticles have been intravenously administrated through a tail vein and forced to cross the blood-brain barrier via a d.c. field gradient of 3000 Oe/cm. A surgically attached two-channel electroencephalography headmount has directly measured the modulation of intrinsic electric waveforms by an external a.c. 100-Oe magnetic field in a frequency range of 0-20 Hz. Results: The modulated signal has reached the strength comparable to that due the regular neural activity. Conclusion: The study opens a pathway to use multifunctional nanoparticles to control intrinsic fields deep in the brain.

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Magnetoelectric 'spin' on stimulating the brain

Abstract

Keywords

ASJC Scopus subject areas

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