Magnetoelectric 'spin' on stimulating the brain

Rakesh Guduru, Ping Liang, J. Hong, Alexandra Rodzinski, Ali Hadjikhani, Jeffrey Horstmyer, Ernest Levister, Sakhrat Khizroev

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Aim: The in vivo study on imprinting control region mice aims to show that magnetoelectric nanoparticles may directly couple the intrinsic neural activity-induced electric fields with external magnetic fields. Methods: Approximately 10 μg of CoFe2O4-BaTiO3 30-nm nanoparticles have been intravenously administrated through a tail vein and forced to cross the blood-brain barrier via a d.c. field gradient of 3000 Oe/cm. A surgically attached two-channel electroencephalography headmount has directly measured the modulation of intrinsic electric waveforms by an external a.c. 100-Oe magnetic field in a frequency range of 0-20 Hz. Results: The modulated signal has reached the strength comparable to that due the regular neural activity. Conclusion: The study opens a pathway to use multifunctional nanoparticles to control intrinsic fields deep in the brain.

Original languageEnglish (US)
Pages (from-to)2051-2061
Number of pages11
Issue number13
StatePublished - Jul 1 2015


  • magnetoelectric nanoparticles
  • nanoengineering the brain
  • noninvasive brain stimulation

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)


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