Magnetoelastic transducers for monitoring coagulation, clot inhibition, and fibrinolysis

Libby G. Puckett, Jaime K. Lewis, Aaron Urbas, Xiangdong Cui, Dayong Gao, Leonidas G. Bachas

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Magnetoelastic transduction has been used to detect and monitor the viscosity changes that occur during the biological reactions of coagulation and fibrinolysis. Magnetoelastic sensors can be used, because the characteristic resonance frequency of the magnetoelastic strip shifts in response to the changes in fluid viscosity. At a set frequency, the output signal can be obtained over time to develop a coagulation and/or dissolution profile, which display the change in viscosity of a plasma sample that has undergone either coagulation or fibrinolysis. For coagulation screening, an exogenous tissue factor is added to an anticoagulated plasma sample to initiate coagulation. Further studies were performed to investigate fibrinolysis through the addition of plasmin. Plasmin is used in two different ways - as a competitive inhibitor before the initiation of clotting and also as a protease to dissolve the previously formed clot. This method is a viable option for the monitoring of processes that are paramount to maintaining hemostasis.

Original languageEnglish (US)
Pages (from-to)1737-1743
Number of pages7
JournalBiosensors and Bioelectronics
Volume20
Issue number9
DOIs
StatePublished - Mar 15 2005
Externally publishedYes

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Keywords

  • Blood coagulation
  • Fibrinolysis
  • Magnetoelastic transduction
  • Plasmin
  • Thromboplastin

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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