Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers

Ajeet Kaushik, Rahul D. Jayant, Roozbeh Nikkhah-Moshaie, Vinay Bhardwaj, Upal Roy, Zaohua Huang, Ariel Ruiz, Adriana Yndart, Venkata Atluri, Nazira El-Hage, Kamel Khalili, Madhavan Nair

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ∼20 nm, 10 mg/kg, across BBB in C57Bl/J mice. Delivered MENCs were uniformly distributed inside the brain, and were non-toxic to brain and other major organs, such as kidney, lung, liver, and spleen, and did not affect hepatic, kidney and neurobehavioral functioning.

Original languageEnglish (US)
Article number25309
JournalScientific reports
Volume6
DOIs
StatePublished - May 4 2016

ASJC Scopus subject areas

  • General

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