Magnetic Resonance–Guided Laser Ablation for the Treatment of Recurrent Dural-Based Lesions: A Series of Five Cases

Michael E. Ivan, Roberto Jose Diaz, Michael H. Berger, Gregory W. Basil, David A. Osiason, Thomas Plate, Amanda Wallo, Ricardo J Komotar

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background and Objective Magnetic resonance-guided laser-induced thermotherapy (MR-LITT) is a minimally invasive technique that shows promise in neuro-oncology because of its superiority in delivering precise minimally invasive thermal energy with minimal collateral damage. In this analysis, we investigate initial data on the effect of MR-LITT on dural-based lesions. Methods Five patients were identified with dural-based lesions (4 meningiomas, 1 solitary fibrous tumor) with clear evidence of radiologic progression. In all 5 cases, the tumors were localized to the lateral convexity or paramedian locations in the supratentorial space. All patients received MR-LITT and then a follow-up magnetic resonance imaging scan at 24 hours after treatment, at 1 month, and at each subsequent follow-up visit. Local control of the ablated tumor was evaluated with radiographic follow-up and symptomatic progression-free survival was recorded. Results Five LITT treatments were performed on 5 patients with an average age of 65.2 years. The average tumor volume was 29.7 cm3 and ablation dosage was 12.4 W. On average, 80% of the pretreatment lesion volume was ablated. The mean follow-up time was 59.3 weeks. In total, 2 patients (1 with an anaplastic meningioma and 1 with a solitary fibrous tumor) had radiographic evidence of disease progression. In the observed time of the 3 patients with no progression, there was a 52% reduction in tumor volume. There were no major perioperative complications. Conclusions MR-LITT is a promising technology for dural-based lesion treatment. This initial study demonstrates that MR-LITT is safe and offers several advantages over open surgical treatment. Randomized studies are needed to evaluate its role as a treatment adjunct.

Original languageEnglish (US)
Pages (from-to)162-170
Number of pages9
JournalWorld Neurosurgery
StatePublished - Feb 1 2017


  • Brain tumors
  • Dural-based lesions
  • Laser-induced thermotherapy
  • Magnetic resonance-guided laser-induced thermotherapy
  • Meningiomas
  • Minimally invasive neurosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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