Magnetic resonance spectroscopic imaging in human brains

James W. Hugg, Gerald B. Matson, Andrew A. Maudsley, Donald B. Twieg, Dominique Sappey-Marinier, Michael W. Weiner

Research output: Chapter in Book/Report/Conference proceedingConference contribution


An attempt was made to use 31P magnetic resonance spectroscopic imaging (MRSI) for evaluation of human brain disease. An improved RF coil was constructed, a protocol was developed using a 3-D spin-echo phase-encoding method, and patients and normal volunteers were studied. The RF coil provided homogeneous B1 over a large volume and improved sensitivity. The results demonstrate the marked advantage of 31P-MRSI over single-volume 31P-mRS techniques and the clinical value of 31P-MRSI for evaluation of patients with brain disease. Information was derived from regions of brain outside of the primary diseased volume and decreased metabolite concentrations were detected in regions previously though to be uninvolved by disease. The ability to sum over voxels facilitated quantitation over irregular, anatomically significant volumes.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Number of pages2
Editionpt 1
ISBN (Print)0879425598
StatePublished - Dec 1 1990
Externally publishedYes
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 1
ISSN (Print)0589-1019


OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


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