Magnetic Resonance Imaging Observations of Blood-Brain-Barrier Permeability in an Animal Model of Brain Injury

John Ford, Andrew K W Wood, Thomas J. Van Winkle, Harold L. Kundel

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Rationale and Objectives. Knowledge of the in vivo relaxivity of paramagnetic contrast agents is important in the accurate measurement of the permeability of the blood-brain barrier (BBB). This study was aimed at developing an animal model for the magnetic resonance (MR) imaging investigation of injuries to the BBB. Methods. MR imaging (1.9 T) was performed in 18 rats with acute, stable injuries to the brain caused by freezing. After injection of gadodiamide (0.05-0.20 mmol/kg), estimates were made of BBB permeability, leakage space, and relaxivity (also measured in saline). Results. The BBB was always disrupted at the injured site (permeability = 0.038 min -1 ± 0.0006). The central area of necrosis and the periphery of edema showed substantial differences in leakage space and relaxivity. The relaxivity of gadodiamide was much greater at the injured site than in saline. Conclusion. The in vivo relaxivity at a site of pathologic change in the brain may be substantially greater than that measured in aquo.

Original languageEnglish (US)
Pages (from-to)115-126
Number of pages12
JournalAcademic Radiology
Volume4
Issue number2
StatePublished - Feb 1997
Externally publishedYes

Fingerprint

gadodiamide
Blood-Brain Barrier
Brain Injuries
Permeability
Animal Models
Magnetic Resonance Imaging
Contrast Media
Freezing
Edema
Necrosis
Injections
Wounds and Injuries
Brain

Keywords

  • Blood-brain barrier
  • Brain, injuries
  • Brain, MR
  • Gadolinium

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Magnetic Resonance Imaging Observations of Blood-Brain-Barrier Permeability in an Animal Model of Brain Injury. / Ford, John; Wood, Andrew K W; Van Winkle, Thomas J.; Kundel, Harold L.

In: Academic Radiology, Vol. 4, No. 2, 02.1997, p. 115-126.

Research output: Contribution to journalArticle

Ford, John ; Wood, Andrew K W ; Van Winkle, Thomas J. ; Kundel, Harold L. / Magnetic Resonance Imaging Observations of Blood-Brain-Barrier Permeability in an Animal Model of Brain Injury. In: Academic Radiology. 1997 ; Vol. 4, No. 2. pp. 115-126.
@article{63e7ed79f7cf467a8638bea13721c581,
title = "Magnetic Resonance Imaging Observations of Blood-Brain-Barrier Permeability in an Animal Model of Brain Injury",
abstract = "Rationale and Objectives. Knowledge of the in vivo relaxivity of paramagnetic contrast agents is important in the accurate measurement of the permeability of the blood-brain barrier (BBB). This study was aimed at developing an animal model for the magnetic resonance (MR) imaging investigation of injuries to the BBB. Methods. MR imaging (1.9 T) was performed in 18 rats with acute, stable injuries to the brain caused by freezing. After injection of gadodiamide (0.05-0.20 mmol/kg), estimates were made of BBB permeability, leakage space, and relaxivity (also measured in saline). Results. The BBB was always disrupted at the injured site (permeability = 0.038 min -1 ± 0.0006). The central area of necrosis and the periphery of edema showed substantial differences in leakage space and relaxivity. The relaxivity of gadodiamide was much greater at the injured site than in saline. Conclusion. The in vivo relaxivity at a site of pathologic change in the brain may be substantially greater than that measured in aquo.",
keywords = "Blood-brain barrier, Brain, injuries, Brain, MR, Gadolinium",
author = "John Ford and Wood, {Andrew K W} and {Van Winkle}, {Thomas J.} and Kundel, {Harold L.}",
year = "1997",
month = "2",
language = "English (US)",
volume = "4",
pages = "115--126",
journal = "Academic Radiology",
issn = "1076-6332",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - Magnetic Resonance Imaging Observations of Blood-Brain-Barrier Permeability in an Animal Model of Brain Injury

AU - Ford, John

AU - Wood, Andrew K W

AU - Van Winkle, Thomas J.

AU - Kundel, Harold L.

PY - 1997/2

Y1 - 1997/2

N2 - Rationale and Objectives. Knowledge of the in vivo relaxivity of paramagnetic contrast agents is important in the accurate measurement of the permeability of the blood-brain barrier (BBB). This study was aimed at developing an animal model for the magnetic resonance (MR) imaging investigation of injuries to the BBB. Methods. MR imaging (1.9 T) was performed in 18 rats with acute, stable injuries to the brain caused by freezing. After injection of gadodiamide (0.05-0.20 mmol/kg), estimates were made of BBB permeability, leakage space, and relaxivity (also measured in saline). Results. The BBB was always disrupted at the injured site (permeability = 0.038 min -1 ± 0.0006). The central area of necrosis and the periphery of edema showed substantial differences in leakage space and relaxivity. The relaxivity of gadodiamide was much greater at the injured site than in saline. Conclusion. The in vivo relaxivity at a site of pathologic change in the brain may be substantially greater than that measured in aquo.

AB - Rationale and Objectives. Knowledge of the in vivo relaxivity of paramagnetic contrast agents is important in the accurate measurement of the permeability of the blood-brain barrier (BBB). This study was aimed at developing an animal model for the magnetic resonance (MR) imaging investigation of injuries to the BBB. Methods. MR imaging (1.9 T) was performed in 18 rats with acute, stable injuries to the brain caused by freezing. After injection of gadodiamide (0.05-0.20 mmol/kg), estimates were made of BBB permeability, leakage space, and relaxivity (also measured in saline). Results. The BBB was always disrupted at the injured site (permeability = 0.038 min -1 ± 0.0006). The central area of necrosis and the periphery of edema showed substantial differences in leakage space and relaxivity. The relaxivity of gadodiamide was much greater at the injured site than in saline. Conclusion. The in vivo relaxivity at a site of pathologic change in the brain may be substantially greater than that measured in aquo.

KW - Blood-brain barrier

KW - Brain, injuries

KW - Brain, MR

KW - Gadolinium

UR - http://www.scopus.com/inward/record.url?scp=0031068813&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031068813&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 115

EP - 126

JO - Academic Radiology

JF - Academic Radiology

SN - 1076-6332

IS - 2

ER -